The prevalence of lymphatic filariasis infection and disease following six rounds of mass drug administration in Mandalay Region, Myanmar.

Autor: Dickson BFR; College of Medicine & Dentistry, Division of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Graves PM; College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.; James Cook University and World Health Organization Collaborating Centre for the Control of Lymphatic Filariasis, Soil Transmitted Helminths and Other Neglected Tropical Diseases, Cairns, Queensland, Australia., Aye NN; Vector Borne Disease Control Unit, Ministry of Health and Sport, Naypyitaw, Myanmar., Nwe TW; Vector Borne Disease Control Unit, Ministry of Health and Sport, Naypyitaw, Myanmar., Wai T; Regional Vector Borne Disease Control Unit, Ministry of Health and Sport, Mandalay, Myanmar., Win SS; World Health Organization, Yangon, Myanmar., Shwe M; General Practitioner, Mandalay, Myanmar., Douglass J; College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.; Center for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Bradbury RS; School of Health, Medical and Applied Sciences, Central Queensland University, North Rockhampton, Queensland, Australia., McBride WJ; College of Medicine & Dentistry, Division of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2018 Nov 12; Vol. 12 (11), pp. e0006944. Date of Electronic Publication: 2018 Nov 12 (Print Publication: 2018).
DOI: 10.1371/journal.pntd.0006944
Abstrakt: Lymphatic filariasis is widely endemic in Myanmar. Despite the establishment of an elimination program in 2000, knowledge of the remaining burden of disease relies predominantly on programmatic information. To assist the program, we conducted an independent cross-sectional household cluster survey to determine the prevalence of filariasis infection, morbidity and mass-drug administration coverage in four townships of the Mandalay Region: Amarapura, Patheingyi, Tada-U and Wundwin. The survey included 1014 individuals from 430 randomly selected households in 24 villages. Household members one year and older were assessed for antigenaemia using immunochromatographic test cards and if positive, microfilaraemia by night-time thick blood smear. Participants 15 years and older were assessed for filariasis morbidity by ultrasound-assisted clinical examination. The overall prevalence of infection was 2.63% by antigenaemia (95% confidence interval (CI) 1.71-4.04%) and 1.03% by microfilaraemia (95%CI 0.59-1.47%). The prevalence of hydrocoele in adult males was 2.78% (95%CI 1.23-6.15%) and of lymphoedema in both genders was 0% (95%CI 0-0.45%). These results indicate the persistence of filarial infection and transmission despite six rounds of annual mass drug administration and highlight the need for further rounds as well as the implementation of morbidity management programs in the country.
Competing Interests: NNA, TWN, TW, and SSW were involved in Myanmar’s National LF Elimination Program at the time of the study. MS works as a self-employed private general practitioner in Mandalay. He volunteered his time to assist with data collection during the study.
Databáze: MEDLINE
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