C 60 fullerene and its nanocomplexes with anticancer drugs modulate circulating phagocyte functions and dramatically increase ROS generation in transformed monocytes.

Autor: Skivka LM; 1Taras Shevchenko National University of Kyiv, 64 Volodymyrska str., Kiev, 01601 Ukraine., Prylutska SV; 1Taras Shevchenko National University of Kyiv, 64 Volodymyrska str., Kiev, 01601 Ukraine., Rudyk MP; 1Taras Shevchenko National University of Kyiv, 64 Volodymyrska str., Kiev, 01601 Ukraine., Khranovska NM; 2National Cancer Institute, 33/43 Lomonosova str., Kiev, 03022 Ukraine., Opeida IV; 1Taras Shevchenko National University of Kyiv, 64 Volodymyrska str., Kiev, 01601 Ukraine., Hurmach VV; 1Taras Shevchenko National University of Kyiv, 64 Volodymyrska str., Kiev, 01601 Ukraine., Prylutskyy YI; 1Taras Shevchenko National University of Kyiv, 64 Volodymyrska str., Kiev, 01601 Ukraine., Sukhodub LF; 3Sumy State University, 2 Rymskogo-Korsakova str., Sumy, 40007 Ukraine., Ritter U; 4Institute of Chemistry and Biotechnology, Technical University of Ilmenau, Weimarer str. 25, 98693 Ilmenau, Germany.
Jazyk: angličtina
Zdroj: Cancer nanotechnology [Cancer Nanotechnol] 2018; Vol. 9 (1), pp. 8. Date of Electronic Publication: 2018 Oct 31.
DOI: 10.1186/s12645-017-0034-0
Abstrakt: Background: C 60 fullerene-based nanoformulations are proposed to have a direct toxic effect on tumor cells. Previous investigations demonstrated that C 60 fullerene used alone or being conjugated with chemotherapeutic agents possesses a potent anticancer activity. The main aim of this study was to investigate the effect of C 60 fullerene and its nanocomplexes with anticancer drugs on human phagocyte metabolic profile in vitro.
Methods: Analysis of the metabolic profile of phagocytes exposed to C 60 fullerene in vitro revealed augmented phagocytic activity and down-regulated reactive nitrogen species generation in these cells. Additionally, cytofluorimetric analysis showed that C 60 fullerene can exert direct cytotoxic effect on normal and transformed phagocytes through the vigorous induction of intracellular reactive oxygen species generation.
Results: Cytotoxic action as well as the pro-oxidant effect of C 60 fullerene was more pronounced toward malignant phagocytes. At the same time, C 60 fullerenes have the ability to down-regulate the pro-oxidant effect of cisplatin on normal cells. These results indicate that C 60 fullerenes may influence phagocyte metabolism and have both pro-oxidant and antioxidant properties.
Conclusions: The antineoplastic effect of C 60 fullerene has been observed by direct toxic effect on tumor cells, as well as through the modulation of the functions of effector cells of antitumor immunity.
Databáze: MEDLINE
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