Evaluation of antibacterial and anticancer properties of poly(3-hydroxybutyrate) functionalized with different amino compounds.

Autor: Abdelwahab MA; Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt. Electronic address: mohamed.abdelwahab@science.tanta.edu.eg., El-Barbary AA; Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt., El-Said KS; Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt., El Naggar SA; Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt., ElKholy HM; Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2019 Feb 01; Vol. 122, pp. 793-805. Date of Electronic Publication: 2018 Oct 25.
DOI: 10.1016/j.ijbiomac.2018.10.164
Abstrakt: The chemical modification of biodegradable poly(3-hydroxybutyrate) (PHB) is useful for biomedical applications. In this study, the transesterification reaction of PHB was carried out under reflux conditions in the presence of 1,4-butanediol to form telechelic PHB-diol. Further modification of PHB-diol into PHB-diacrylate was carried out by the reaction of PHB-diol with acryloyl chloride. PHB-diacrylate was grafted with amino compounds such as 1,4-butanediamine, 1,3-propanediamine, 1,2-ethylenediamine, piperazine, cyclohexylamine, 2,2'-(ethane-1,2-diylbis(oxy)) diethanamine (jeffamine EDR 148) and morpholine via Michael-type addition reaction. The functionalized amino-PHB polymers were characterized by using FTIR and 1 H NMR techniques. XRD showed that amino-PHB polymers have different crystallinity compared with neat PHB. Some biological activities of amino-PHB polymers were determined such as antibacterial, antioxidant and anticancer activities. In this regard, the results showed that PHB-ethylenediamine revealed a potent antibacterial activity against Staphlococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. All amino-PHB polymers under the study showed reasonable antioxidant activity. Among these polymers, PHB-piperazine showed a potent anticancer effect against in vivo Ehrlich ascetic carcinoma bearing mice.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: