Association between three genetic variants in kallikrein 3 and prostate cancer risk.

Autor: Ding WH; Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai 200040, China., Ren KW; Department of Orthopedics, the Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China., Yue C; Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China., Zou JG; Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China., Zuo L; Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China jiaomin0324@126.com dou20140718@sohu.com nj-likky@163.com., Zhang LF; Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China jiaomin0324@126.com dou20140718@sohu.com nj-likky@163.com., Bai Y; Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China., Okada A; Department of Nephrourology, Nagoya City University Graduate School of Medical Sciences, Aichi 4678601, Japan., Yasui T; Department of Nephrourology, Nagoya City University Graduate School of Medical Sciences, Aichi 4678601, Japan., Mi YY; Department of Urology, Third Affiliated Hospital of Nantong University (Affiliated Hospital of Jiangnan University), 585 Xingyuan Road, Wuxi 214041, China jiaomin0324@126.com dou20140718@sohu.com nj-likky@163.com.
Jazyk: angličtina
Zdroj: Bioscience reports [Biosci Rep] 2018 Nov 30; Vol. 38 (6). Date of Electronic Publication: 2018 Nov 30 (Print Publication: 2018).
DOI: 10.1042/BSR20181151
Abstrakt: Background: Epidemiological studies have assessed the association between kallikrein 3 (KLK3) polymorphisms and prostate cancer (PCa) susceptibility. However, published data on this association are somewhat inconclusive.
Methods: Articles investigating the association between three KLK3 (rs1058205, rs2735839, and rs266882) variants and PCa susceptibility were searched from online databases, which included 35,838 patients and 36,369 control participants. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to demonstrate the strength of the association. We also utilized ELISA to detect serum expression of KLK3. In addition, in silico tools were adopted to evaluate the relationship of KLK3 expression and PCa survival time.
Results: The overall results indicated that polymorphism T>C of rs1058205 was associated with decreased risk of PCa (allele contrast: OR = 0.75, 95% CI = 0.64-0.88, P heterogeneity < 0.001; homozygote comparison: OR = 0.58, 95% CI = 0.42-0.81, P heterogeneity < 0.001), particularly in Caucasian population (allele contrast: OR = 0.77, 95% CI = 0.65-0.91, P heterogeneity < 0.001; homozygote comparison: OR = 0.58, 95% CI = 0.41-0.82, P heterogeneity < 0.001). No association was observed between the polymorphism A>G of rs2735839 and risk of PCa. In addition, no association was observed between polymorphism A>G of rs266882 and risk of PCa. Serum KLK3 levels in PCa patients carrying CC/CT genotypes were statistically lower than those carrying TT genotypes. Conclusion : This meta-analysis suggests that rs1058205 polymorphism of KLK3 is a risk factor for PCa development, polymorphism T>C of rs1058205 is associated with decreased susceptibility to PCa particularly in Caucasian population.
(© 2018 The Author(s).)
Databáze: MEDLINE
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