Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial.

Autor: Cook DA; BC Centre for Disease Control, Vancouver, British Columbia, Canada.; BC Cancer Agency, Vancouver, British Columbia, Canada., Krajden M; BC Centre for Disease Control, Vancouver, British Columbia, Canada.; Lower Mainland Pathology and Laboratory Medicine, Vancouver, British Columbia, Canada.; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Brentnall AR; Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Queen Mary University of London, London, United Kingdom., Gondara L; BC Cancer Agency, Vancouver, British Columbia, Canada., Chan T; Lower Mainland Pathology and Laboratory Medicine, Vancouver, British Columbia, Canada., Law JH; Lower Mainland Pathology and Laboratory Medicine, Vancouver, British Columbia, Canada., Smith LW; BC Cancer Agency, Vancouver, British Columbia, Canada., van Niekerk DJ; BC Cancer Agency, Vancouver, British Columbia, Canada.; Lower Mainland Pathology and Laboratory Medicine, Vancouver, British Columbia, Canada.; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Ogilvie GS; BC Centre for Disease Control, Vancouver, British Columbia, Canada.; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Coldman AJ; BC Cancer Agency, Vancouver, British Columbia, Canada.; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Warman R; Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Queen Mary University of London, London, United Kingdom., Reuter C; Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Queen Mary University of London, London, United Kingdom., Cuzick J; Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Queen Mary University of London, London, United Kingdom., Lorincz AT; Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Queen Mary University of London, London, United Kingdom.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2019 May 15; Vol. 144 (10), pp. 2587-2595. Date of Electronic Publication: 2018 Dec 24.
DOI: 10.1002/ijc.31976
Abstrakt: Human papillomavirus (HPV)-based cervical cancer screening requires triage of HPV positive women to identify those at risk of cervical intraepithelial neoplasia grade 2 (CIN2) or worse. We conducted a blinded case-control study within the HPV FOCAL randomized cervical cancer screening trial of women aged 25-65 to examine whether baseline methylation testing using the S5 classifier provided triage performance similar to an algorithm relying on cytology and HPV genotyping. Groups were randomly selected from women with known HPV/cytology results and pathology outcomes. Group 1: 104 HPV positive (HPV+), abnormal cytology (54 CIN2/3; 50 (© 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)
Databáze: MEDLINE
Externí odkaz: