Serum sclerostin and irisin as predictive markers for atherosclerosis in Egyptian type II diabetic female patients: A case control study.

Autor: Saadeldin MK; Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.; Department of Biochemistry, National Institute of Diabetes and Endocrinology (NIDE), Cairo, Egypt.; Faculty of Biotechnology, October University for Modern Sciences and Arts, 6th October City, Cairo, Egypt., Elshaer SS; Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Emara IA; Department of Biochemistry, National Institute of Diabetes and Endocrinology (NIDE), Cairo, Egypt., Maged M; Faculty of Biotechnology, October University for Modern Sciences and Arts, 6th October City, Cairo, Egypt., Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Nov 07; Vol. 13 (11), pp. e0206761. Date of Electronic Publication: 2018 Nov 07 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0206761
Abstrakt: Diabetes mellitus represents a major independent risk factor for developing fatal cardiovascular diseases (CVDs) presumably through accelerating atherosclerosis; the underlying cause of most CVDs. Notably, this relative risk is reported to be higher in women than men. Endeavors directed towards identifying novel reliable predictive biomarkers are immensely thereby urged to improve the long-term outcome in these diabetic female patients. Sclerostin (SOST) is a Wnt signaling antagonist whereas irisin is a muscle-derived factor released after exercising which enhances browning of white adipose tissue. Emerging lines of evidence hint at potential crosstalk between them and CVDs. The present study aimed to assess the serum levels of SOST and irisin in Egyptian type 2 diabetic (T2DM) female patients with and without atherosclerosis and explore the possible relationship between both markers and other studied parameters among the studied cohorts. In this case-control study, 69 female subjects were enrolled; 39 type 2 diabetes patients with atherosclerosis (T2DM+ATHR), 22 type 2 diabetes patients without atherosclerosis (T2DM-ATHR) and 8 healthy controls. Their serum levels of SOST and irisin were assessed using ELISA. Significant increase in SOST levels were found in T2DM+ATHR compared to T2DM-ATHR and control (259.9 ±17.98 vs. 165.8±13.12 and 142.0±13.31 pg/mL respectively, P<0.001). Conversely, irisin levels were significantly lower in T2DM+ATHR (P<0.001) and T2DM-ATHR (P<0.01) compared to the control group (32.91±2.545 and 58.55±13.19 vs. 473.6±112.7 pg/mL). Interestingly, significant correlations between the levels of SOST and both irisin and fasting blood glucose were noticed in T2DM+ATHR group (r = 0.3754 and 0.3381 respectively, P<0.05). In conclusion, to the best of our knowledge, this study is the first to demonstrate the correlation between SOST and irisin levels in atherosclerotic T2DM female patients implying their potential implication in diabetic cardiovascular pathophysiology and supporting their use as reliable diagnostic/prognostic biomarkers for monitoring and preventing CVDs progression of T2DM female patients.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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