α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations.

Autor: Zamorina SA; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.; Perm State National Research University, Perm, Russia., Timganova VP; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia. timganovavp@gmail.com., Bochkova MS; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia., Khramtsov PV; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.; Perm State National Research University, Perm, Russia., Fomicheva KA; Perm State National Research University, Perm, Russia., Rayev MB; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.; Perm State National Research University, Perm, Russia.; Ural Federal University, Yekaterinburg, Russia., Chereshnev VA; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.; Perm State National Research University, Perm, Russia.; Ural Federal University, Yekaterinburg, Russia.
Jazyk: angličtina
Zdroj: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2018 Sep; Vol. 482 (1), pp. 210-213. Date of Electronic Publication: 2018 Nov 06.
DOI: 10.1134/S0012496618050113
Abstrakt: The effect of native α-fetoprotein (AFP) on the conversion of naïve T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naïve T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-γ by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.
Databáze: MEDLINE
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