Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation.
| Autor: | McGough MAP; 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.; 2Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee., Shiels SM; 3U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas., Boller LA; 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.; 2Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee., Zienkiewicz KJ; 4Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee., Duvall CL; 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee., Wenke JC; 3U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas., Guelcher SA; 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.; 2Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee.; 4Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee. |
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| Jazyk: | angličtina |
| Zdroj: | Tissue engineering. Part A [Tissue Eng Part A] 2019 Jul; Vol. 25 (13-14), pp. 949-963. Date of Electronic Publication: 2019 Jan 09. |
| DOI: | 10.1089/ten.TEA.2018.0223 |
| Abstrakt: | Impact Statement: The development of autograft extenders is a significant clinical need in bone tissue engineering. We report new settable poly(thioketal urethane)-based autograft extenders that have bone-like mechanical properties and handling properties comparable to calcium phosphate bone cements. These settable autograft extenders remodeled to form new bone in a biologically stringent intertransverse process model of bone formation that does not heal when treated with calcium phosphate bone void fillers or cements alone. This is the first study to report settable autograft extenders with bone-like strength and handling properties comparable to ceramic bone cements, which have the potential to improve treatment of bone fractures and other orthopedic conditions. |
| Databáze: | MEDLINE |
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