Low-level transcutaneous vagus nerve stimulation attenuates cardiac remodelling in a rat model of heart failure with preserved ejection fraction.

Autor: Zhou L; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China., Filiberti A; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Humphrey MB; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Fleming CD; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Scherlag BJ; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Po SS; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Stavrakis S; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Jazyk: angličtina
Zdroj: Experimental physiology [Exp Physiol] 2019 Jan; Vol. 104 (1), pp. 28-38. Date of Electronic Publication: 2018 Nov 29.
DOI: 10.1113/EP087351
Abstrakt: New Findings: What is the central question of this study? What is the effect of chronic intermittent low-level transcutaneous vagus nerve stimulation on cardiac inflammation, fibrosis and diastolic dysfunction in a rat model of heart failure with preserved ejection fraction? What is the main finding and its importance? In salt-sensitive rats fed with high salt diet, low-level transcutaneous vagus nerve stimulation significantly attenuated blood pressure elevation, ameliorated diastolic function, and attenuated left ventricular inflammation and fibrosis compared to the sham group. Further studies to examine the efficacy of this novel treatment in humans are warranted.
Abstract: Inflammation and fibrosis play a central role in the development of heart failure with preserved ejection fraction (HFpEF). We previously showed that low-level, transcutaneous stimulation of the vagus nerve at the tragus (LLTS) is anti-inflammatory. We investigated the effect of chronic intermittent LLTS on cardiac inflammation, fibrosis and diastolic dysfunction in a rat model of HFpEF. Dahl salt-sensitive (DS) rats were randomized in three groups: low salt (LS, 0.3% NaCl; n = 12; control group without stimulation) and high salt (HS, 4% NaCl) with either active (n = 18) or sham (n = 18) LLTS at 7 weeks of age. After 6 weeks of diet (baseline), sham or active LLTS (20 Hz, 2 mA, 0.2 ms) was implemented for 30 min daily for 4 weeks. Echocardiography was performed at baseline and 4 weeks after treatment (endpoint). At endpoint, left ventricle (LV) histology and gene expression were examined. After 6 weeks of diets, HS rats developed hypertension and LV hypertrophy compared to LS rats. At endpoint, LLTS significantly attenuated blood pressure elevation, prevented the deterioration of diastolic function and improved LV circumferential strain, compared to the HS sham group. LV inflammatory cell infiltration and fibrosis were attenuated in the HS active compared to the HS sham group. Pro-inflammatory and pro-fibrotic genes (tumour necrosis factor, osteopontin, interleukin (IL)-11, IL-18 and IL-23A) were differentially altered in the two groups. Chronic intermittent LLTS ameliorates diastolic dysfunction, and attenuates cardiac inflammation and fibrosis in a rat model of HFpEF, suggesting that LLTS may be used clinically as a novel non-invasive neuromodulation therapy in HFpEF.
(© 2018 The Authors. Experimental Physiology © 2018 The Physiological Society.)
Databáze: MEDLINE
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