Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients.

Autor: Ohno T; a Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama , Kanagawa , Japan., Meguro A; a Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama , Kanagawa , Japan., Takeuchi M; a Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama , Kanagawa , Japan., Yamane T; a Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama , Kanagawa , Japan., Teshigawara T; a Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama , Kanagawa , Japan.; b Yokosuka Chuoh Eye Clinic , Yokohama , Kanagawa , Japan.; c Tsurumi Chuoh Eye Clinic , Yokohama , Kanagawa , Japan., Kitaichi N; d Department of Ophthalmology, Health Sciences University of Hokkaido , Sapporo , Hokkaido , Japan.; e Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo , Hokkaido , Japan., Horie Y; d Department of Ophthalmology, Health Sciences University of Hokkaido , Sapporo , Hokkaido , Japan., Namba K; e Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo , Hokkaido , Japan., Ohno S; d Department of Ophthalmology, Health Sciences University of Hokkaido , Sapporo , Hokkaido , Japan.; e Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo , Hokkaido , Japan., Nakao K; f Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Kagoshima , Japan., Sakamoto T; f Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Kagoshima , Japan., Sakai T; g Department of Ophthalmology, Jikei University School of Medicine , Tokyo , Minato-ku , Japan., Nakano T; g Department of Ophthalmology, Jikei University School of Medicine , Tokyo , Minato-ku , Japan., Keino H; h Department of Ophthalmology, Kyorin University School of Medicine , Tokyo , Mitaka , Japan., Okada AA; h Department of Ophthalmology, Kyorin University School of Medicine , Tokyo , Mitaka , Japan., Takeda A; i Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Fukuoka , Japan., Fukuhara T; i Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Fukuoka , Japan., Mashimo H; j Department of Ophthalmology, Japan Community Health Care Organization Osaka Hospital , Osaka , Osaka , Japan., Ohguro N; j Department of Ophthalmology, Japan Community Health Care Organization Osaka Hospital , Osaka , Osaka , Japan., Oono S; k Department of Ophthalmology, Saga University Faculty of Medicine , Saga , Saga , Japan., Enaida H; k Department of Ophthalmology, Saga University Faculty of Medicine , Saga , Saga , Japan., Okinami S; l Department of Ophthalmology, Kurashiki Central Hospital , Okayama , Kurashiki , Japan., Mizuki N; a Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama , Kanagawa , Japan.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2019; Vol. 27 (5), pp. 699-705. Date of Electronic Publication: 2018 Nov 05.
DOI: 10.1080/09273948.2018.1523438
Abstrakt: Purpose : To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population. Methods : We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms (SNPs) in ARMC9 . We also performed imputation analysis of the ARMC9 region and 195 imputed SNPs were included in the statistical analysis. Results : We observed an increased frequency of the A allele of rs28690417 in patients compared with controls ( P  = 0.0097, odds ratio (OR) = 1.46). The A allele had a dominant effect on VKH disease risk ( P  = 0.011, OR = 1.51). However, these significant differences disappeared after Bonferroni correction (corrected P  > 0.05). The remaining 201 SNPs did not show any significant association with disease risk. Conclusions : Our study suggests that ARMC9 variants do not play a critical role in the development of VKH disease.
Databáze: MEDLINE
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