Phytol as an anticarcinogenic and antitumoral agent: An in vivo study in swiss mice with DMBA-Induced breast cancer.

Autor: de Alencar MVOB; Postgraduate Program in Biomedical Sciences, Federal University of Piauí, Parnaíba, Piauí, Brazil., Islam MT; Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., de Lima RMT; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil., Paz MFCJ; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil., Dos Reis AC; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil., da Mata AMOF; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil., Filho JWGO; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil., Cerqueira GS; Department of Morphology, Federal University of Ceará, Fortaleza, Ceará, Brazil., Ferreira PMP; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil.; Department of Biophysics and Physiology, Laboratory of Experimental Cancerology, Federal University of Piauí, Teresina, Piauí, Brazil., E Sousa JMC; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil.; Department of Biological Sciences, Federal University of Piauí, Picos, Piauí, Brazil., Mubarak MS; Department of Chemistry, The University of Jordan, Amman 11942, Jordan., Melo-Cavalcante AAC; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil.
Jazyk: angličtina
Zdroj: IUBMB life [IUBMB Life] 2019 Feb; Vol. 71 (2), pp. 200-212. Date of Electronic Publication: 2018 Nov 05.
DOI: 10.1002/iub.1952
Abstrakt: Phytol (PHY) (3,7,11,15-tetramethylhexadec-2-en-1-ol) exhibits various pharmacological properties including toxicity and cytotoxicity, and exerts antitumor activity. Owing to the urgent need of new pharmaceutical formulations for breast cancer therapy, this study aimed at the evaluation of antitumor activity of PHY in 7,12-dimethylbenzanthracene-cancer-induced animal model. Comet assay was employed to evaluate the cytogenetics, DNA repair, and antigenotoxic activities of PHY in neoplastic (breast) and non-neoplastic rodent cells (bone marrow, lymphocytes, and liver). Additionally, hematological, biochemical, histopathological, and immunohistochemical analyses were carried out in experimental animals. Thirty nonpregnant female mice (n = 5) underwent 7 weeks treatment with 6 mg/kg pro-carcinogen, PHY (4 mg/kg), and cyclophosphamide (25 mg/kg). Induction of cancer was confirmed by histopathology and immunohistochemistry for Ki-67. Results suggest that PHY exhibits low toxicity in comparison with other groups in hematological, biochemical, histopathological, and organ size parameters. Additionally, PHY showed modulatory effects on the pro-carcinogen, and induced genotoxicity and apoptosis in breast cancer cells. Furthermore, it showed a DNA damage repair capacity in mouse lymphocytes. These data indicate that PHY may have the potential as an anticancer candidate in pharmaceutical consumption. © 2018 IUBMB Life, 71(1):200-212, 2019.
(© 2018 International Union of Biochemistry and Molecular Biology.)
Databáze: MEDLINE
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