Molecular Mechanisms of the Memory Trace.

Autor: Asok A; Department of Neuroscience, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA. Electronic address: a.asok@columbia.edu., Leroy F; Department of Neuroscience, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Rayman JB; Department of Neuroscience, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Kandel ER; Department of Neuroscience, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Howard Hughes Medical Institute at Columbia University, New York, NY 10032, USA; Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA. Electronic address: erk5@columbia.edu.
Jazyk: angličtina
Zdroj: Trends in neurosciences [Trends Neurosci] 2019 Jan; Vol. 42 (1), pp. 14-22. Date of Electronic Publication: 2018 Oct 31.
DOI: 10.1016/j.tins.2018.10.005
Abstrakt: Over the past half-century, we have gained significant insights into the molecular biology of long-term memory storage at the level of the synapse. In recent years, our understanding of the cellular architecture supporting long-term memory traces has also substantially improved. However, the molecular biology of consolidation at the level of neuronal systems has been relatively neglected. In this opinion article, we first examine our current understanding of the cellular mechanisms of synaptic consolidation. We then outline areas requiring further investigation on how cellular changes contribute to systems consolidation. Finally, we highlight recent findings on the cellular architecture of memory traces in rodents and how the application of new technologies will expand our understanding of systems consolidation at the neural circuit level. In the coming years, this research focus will be critical for understanding the evolution of long-term memories and for enabling the development of novel therapeutics which embrace the dynamic nature of memories.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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