Correlation between tumor glucose metabolism and multiparametric functional MRI (IVIM and R2*) metrics in cervical carcinoma: Evidence from integrated 18 F-FDG PET/MR.
Autor: | Li-Ou Z; Department of Radiology, Shengjing Hospital of China Medical University, P.R. China., Hong-Zan S; Department of Radiology, Shengjing Hospital of China Medical University, P.R. China., Xiao-Xi B; Department of Radiology, Shengjing Hospital of China Medical University, P.R. China., Zhong-Wei C; Department of Radiology, Shengjing Hospital of China Medical University, P.R. China., Zai-Ming L; Department of Radiology, Shengjing Hospital of China Medical University, P.R. China., Jun X; Department of Radiology, Shengjing Hospital of China Medical University, P.R. China., Qi-Yong G; Department of Radiology, Shengjing Hospital of China Medical University, P.R. China. |
---|---|
Jazyk: | angličtina |
Zdroj: | Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2019 Jun; Vol. 49 (6), pp. 1704-1712. Date of Electronic Publication: 2018 Nov 03. |
DOI: | 10.1002/jmri.26557 |
Abstrakt: | Background: Multiparameter, multimodality 18 F-FDG PET/MRI holds great potential for the diagnosis of cervical cancer based on the correlation between tumor glucose metabolism and imaging parameters. Purpose: To characterize the heterogeneity of tumor glucose metabolism by evaluating the correlation between 18 F-FDG uptake parameters and multiparametric functional MRI metrics in cervical carcinoma. Study Type: Retrospective. Population: Fifty-four patients with cervical carcinoma. Field Strength/sequence: Hybrid PET/MR (3T), multi-b DWI, and R2* mapping. Assessment: The maximum and mean standardized uptake values (SUV Statistical Tests: Single-factor Spearman rank and Pearson correlation analysis and multiple linear regression (MLR) analysis were applied. Results: R2*, D, and f have different degrees of correlation (moderate, weak, moderately strong correlation, respectively) with SUV Data Conclusion: The functional MRI sequence parameters R2*, f, and D can provide information on the hypoxic condition, blood perfusion, and molecular diffusion of the tumor. 18 F-FDG PET/MR multi-imaging technique can be adopted to evaluate the heterogeneity of glucose metabolism in cervical carcinoma. Level of Evidence: 3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;49:1704-1712. (© 2018 International Society for Magnetic Resonance in Medicine.) |
Databáze: | MEDLINE |
Externí odkaz: |