Evolution and Structural Characteristics of Plant Voltage-Gated K + Channels.

Autor:	Jegla T; Department of Biology and Huck Institute for the Life Sciences, Penn State University, 230 Life Sciences Building, University Park, Pennsylvania 16802 tjj3@psu.edu sma3@psu.edu., Busey G; Department of Biology, Penn State University, 225 Life Sciences Building, University Park, Pennsylvania 16802., Assmann SM; Department of Biology, Penn State University, 354 North Frear, University Park, Pennsylvania 16802 tjj3@psu.edu sma3@psu.edu.
Jazyk:	angličtina
Zdroj:	The Plant cell [Plant Cell] 2018 Dec; Vol. 30 (12), pp. 2898-2909. Date of Electronic Publication: 2018 Nov 01.
DOI:	10.1105/tpc.18.00523
Abstrakt:	Plant voltage-gated K + channels have been referred to as "plant Shakers" in reference to animal Shaker channels, the first K + channels identified. Recent advances in our knowledge of K + channel evolution and structure have significantly deepened the divide between these plant and animal K + channels, suggesting that it is time to completely retire the "plant Shaker" designation. Evolutionary genomics reveals that plant voltage-gated K + channels and metazoan Shakers derive from distinct prokaryotic ancestors. The plant channels belong to a lineage that includes cyclic nucleotide-gated channels and metazoan ether-à-go-go and hyperpolarization-activated, cyclic nucleotide-gated channels. We refer to this lineage as the CNBD channel superfamily, because all these channels share a cytoplasmic gating domain homologous to cyclic nucleotide binding domains. The first structures of CNBD superfamily channels reveal marked differences in coupling between the voltage sensor and ion-conducting pore relative to metazoan Shaker channels. Viewing plant voltage-gated K + channel function through the lens of CNBD superfamily structures should lead to insights into how these channels are regulated. (© 2018 American Society of Plant Biologists. All rights reserved.)
Databáze:	MEDLINE
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