| Autor: |
Elgawish RA; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt. reemshab@gmail.com., Abdelrazek HMA; Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt., Ismail SAA; Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt., Loutfy NM; Department of Plant Protection, Faculty of Agriculture, Suez Canal University, Ismailia, 41522, Egypt., Soliman MTA; Department of Clinical Pathology, College of Applied Medical Sciences, Bisha University, Bisha, Kingdom of Saudi Arabia. |
| Jazyk: |
angličtina |
| Zdroj: |
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2019 Jan; Vol. 26 (1), pp. 199-207. Date of Electronic Publication: 2018 Nov 01. |
| DOI: |
10.1007/s11356-018-3615-5 |
| Abstrakt: |
The effects of fipronil (FPN) on the liver of rats were studied. Rats (n = 6) were treated with 9.7 mg/kg (1/10 of FPN LD 50 ), and other rats (n = 6) received 120 mg/kg of 10% Uncaria tomentosa extract, while a mixture of 9.7 mg/kg FPN and 120 mg/kg of 10% Uncaria tomentosa extract were administered orally to the rats (n = 6) daily for 6 weeks. Body, hepatic weights, liver enzymes, and lipid profile were determined. Hepatic activities of MDA, TNO, TAC, TNF-α, and IL-6 in liver homogenate were measured. Immunohistochemistry of NF-kB and liver histopathology were performed. Fipronil-treated rats had a significant (P = 0.02) lower weight gain. Moreover, relative liver weight was significantly (P = 0.003) increased in FPN-treated rats. Rats administrated with FPN exhibited a significantly (P = 0.02) higher liver enzymes and promoted levels of MDA, TNO, TNF-α, and IL-6 (P < 0.0001) than that in the other groups. Immunostaining of NF-κB was increased (P < 0.0001) in FPN-treated rats. Interestingly, Uncaria tomentosa alone or with FPN decreased the liver immunostaining of NF-κB. In conclusion, FPN produced liver injury through lipid peroxidation and stimulation of NF-κB. However, Uncaria tomentosa combated the oxidative stress and liver damage induced by FPN via inhibition of NF-κB. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink