Iron: an essential nutrient for Aspergillus fumigatus and a fulcrum for pathogenesis.

Autor:	Matthaiou EI; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford., Sass G; California Institute for Medical Research, San Jose., Stevens DA; California Institute for Medical Research, San Jose.; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Hsu JL; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford.
Jazyk:	angličtina
Zdroj:	Current opinion in infectious diseases [Curr Opin Infect Dis] 2018 Dec; Vol. 31 (6), pp. 506-511.
DOI:	10.1097/QCO.0000000000000487
Abstrakt:	Purpose of Review: Aspergillus fumigatus is a ubiquitous saprophytic fungus that can cause life-threatening invasive aspergillosis in immunocompromised patients. Apart from the immune status of the host only a few characterized virulence factors have been identified. In this review, we describe the role of iron in the manifestation of A. fumigatus virulence. Recent Findings: We gathered recent clinical evidence suggesting that tissue iron overload increases the risk of invasive aspergillosis occurrence. Furthermore, we summarize the mechanisms that A. fumigatus employs to achieve iron homeostasis and their importance in A. fumigatus proliferation in vitro. We describe two recent in-vivo models that clearly demonstrate the importance of iron in A. fumigatus growth and invasion. Summary: Based on these recent findings, therapy aimed at managing A. fumigatus iron homeostasis locally could make conditions more favorable to the host.
Databáze:	MEDLINE
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