Adiponectin in Relation to Coronary Plaque Characteristics on Radiofrequency Intravascular Ultrasound and Cardiovascular Outcome.

Autor:	Marino BCA; Department of Cardiology, Erasmus MC, Rotterdam - the Netherlands.; Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG - Brasil., Buljubasic N; Department of Cardiology, Erasmus MC, Rotterdam - the Netherlands., Akkerhuis M; Department of Cardiology, Erasmus MC, Rotterdam - the Netherlands., Cheng JM; Department of Cardiology, Erasmus MC, Rotterdam - the Netherlands., Garcia-Garcia HM; Washington Hospital Center, Washington DC - USA., Regar E; Department of Cardiology, Erasmus MC, Rotterdam - the Netherlands.; University Hospital of Zurich, Zurich - Switzerland., Geuns RV; Department of Cardiology, Erasmus MC, Rotterdam - the Netherlands., Serruys PW; Imperial College, London - United Kingdom., Boersma E; Department of Cardiology, Erasmus MC, Rotterdam - the Netherlands., Kardys I; Department of Cardiology, Erasmus MC, Rotterdam - the Netherlands.
Jazyk:	English; Portuguese
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2018 Sep; Vol. 111 (3), pp. 345-353.
DOI:	10.5935/abc.20180172
Abstrakt:	Background: Prospective data on the associations of adiponectin with in-vivo measurements of degree, phenotype and vulnerability of coronary atherosclerosis are currently lacking. Objective: To investigate the association of plasma adiponectin with virtual histology intravascular ultrasound (VH-IVUS)-derived measures of atherosclerosis and with major adverse cardiac events (MACE) in patients with established coronary artery disease. Methods: In 2008-2011, VH-IVUS of a non-culprit non-stenotic coronary segment was performed in 581 patients undergoing coronary angiography for acute coronary syndrome (ACS, n = 318) or stable angina pectoris (SAP, n = 263) from the atherosclerosis-intravascular ultrasound (ATHEROREMO-IVUS) study. Blood was sampled prior to coronary angiography. Coronary plaque burden, tissue composition, high-risk lesions, including VH-IVUS-derived thin-cap fibroatheroma (TCFA), were assessed. All-cause mortality, ACS, unplanned coronary revascularization were registered during a 1-year-follow-up. All statistical tests were two-tailed and p-values < 0.05 were considered statistically significant. Results: In the full cohort, adiponectin levels were not associated with plaque burden, nor with the various VH-tissue types. In SAP patients, adiponectin levels (median[IQR]: 2.9(1.9-3.9) µg/mL) were positively associated with VH-IVUS derived TCFA lesions, (OR[95%CI]: 1.78[1.06-3.00], p = 0.030), and inversely associated with lesions with minimal luminal area (MLA) ≤ 4.0 mm2 (OR[95%CI]: 0.55[0.32-0.92], p = 0.025). In ACS patients, adiponectin levels (median[IQR]: 2.9 [1.8-4.1] µg/mL)were not associated with plaque burden, nor with tissue components. Positive association of adiponectin with death was present in the full cohort (HR[95%CI]: 2.52[1.02-6.23], p = 0.045) and (borderline) in SAP patients (HR[95%CI]: 8.48[0.92-78.0], p = 0.058). In ACS patients, this association lost statistical significance after multivariable adjustment (HR[95%CI]: 1.87[0.67-5.19], p = 0.23). Conclusion: In the full cohort, adiponectin levels were associated with death but not with VH-IVUS atherosclerosis measures. In SAP patients, adiponectin levels were associated with VH-IVUS-derived TCFA lesions. Altogether, substantial role for adiponectin in plaque vulnerability remains unconfirmed.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu