Evaluation of the use of tranexamic acid in total knee arthroplasty.
| Autor: | Almeida MDC; Centro de Cirurgia do Joelho, Instituto Nacional de Traumatologia e Ortopedia (Into), Rio de Janeiro, RJ, Brazil., Albuquerque RPE; Centro de Cirurgia do Joelho, Instituto Nacional de Traumatologia e Ortopedia (Into), Rio de Janeiro, RJ, Brazil., Palhares GM; Centro de Cirurgia do Joelho, Instituto Nacional de Traumatologia e Ortopedia (Into), Rio de Janeiro, RJ, Brazil., Almeida JPC; Hospital Federal da Lagoa, Rio de Janeiro, RJ, Brazil., Barretto JM; Centro de Cirurgia do Joelho, Instituto Nacional de Traumatologia e Ortopedia (Into), Rio de Janeiro, RJ, Brazil., Cavanellas N; Centro de Cirurgia do Joelho, Instituto Nacional de Traumatologia e Ortopedia (Into), Rio de Janeiro, RJ, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Revista brasileira de ortopedia [Rev Bras Ortop] 2018 Sep 19; Vol. 53 (6), pp. 761-767. Date of Electronic Publication: 2018 Sep 19 (Print Publication: 2018). |
| DOI: | 10.1016/j.rboe.2018.09.008 |
| Abstrakt: | Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. Methods: 101 patients were randomized into two groups: the tranexamic acid group ( n = 51) and the placebo group ( n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. Results: Comparing the groups, there were statistically significant differences ( p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty. |
| Databáze: | MEDLINE |
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