Helminth-induced IL-4 expands bystander memory CD8 + T cells for early control of viral infection.

Autor: Rolot M; Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Avenue de Cureghem 10, 4000, Liège, Belgium., Dougall AM; Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Avenue de Cureghem 10, 4000, Liège, Belgium., Chetty A; Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University of Cape Town, Cape Town, South Africa, 7925., Javaux J; Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Avenue de Cureghem 10, 4000, Liège, Belgium., Chen T; Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Avenue de Cureghem 10, 4000, Liège, Belgium., Xiao X; Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Avenue de Cureghem 10, 4000, Liège, Belgium., Machiels B; Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Avenue de Cureghem 10, 4000, Liège, Belgium., Selkirk ME; Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK., Maizels RM; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK., Hokke C; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Denis O; Scientific Institute of Public Health, Immunology, Communicable and Infectious Diseases, Rue Engeland 642, 1180, Brussels, Belgium., Brombacher F; Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University of Cape Town, Cape Town, South Africa, 7925.; International Centre for Genetic Engineering and Biotechnology, 7925, Cape Town, South Africa.; South African Medical Research Council (SAMRC), 7925, Cape Town, South Africa., Vanderplasschen A; Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Avenue de Cureghem 10, 4000, Liège, Belgium., Gillet L; Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Avenue de Cureghem 10, 4000, Liège, Belgium., Horsnell WGC; Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University of Cape Town, Cape Town, South Africa, 7925.; Institute of Microbiology and Infection, University of Birmingham, B15 2TT, Birmingham, UK.; Laboratory of Molecular and Experimental Immunology and Neurogenetics, UMR 7355, CNRS-University of Orleans and Le Studium Institute for Advanced Studies, Rue Dupanloup, 45000, Orléans, France., Dewals BG; Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Avenue de Cureghem 10, 4000, Liège, Belgium. bgdewals@uliege.be.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2018 Oct 30; Vol. 9 (1), pp. 4516. Date of Electronic Publication: 2018 Oct 30.
DOI: 10.1038/s41467-018-06978-5
Abstrakt: Infection with parasitic helminths can imprint the immune system to modulate bystander inflammatory processes. Bystander or virtual memory CD8 + T cells (T VM ) are non-conventional T cells displaying memory properties that can be generated through responsiveness to interleukin (IL)-4. However, it is not clear if helminth-induced type 2 immunity functionally affects the T VM compartment. Here, we show that helminths expand CD44 hi CD62L hi CXCR3 hi CD49d lo T VM cells through direct IL-4 signaling in CD8 + T cells. Importantly, helminth-mediated conditioning of T VM cells provided enhanced control of acute respiratory infection with the murid gammaherpesvirus 4 (MuHV-4). This enhanced control of MuHV-4 infection could further be explained by an increase in antigen-specific CD8 + T cell effector responses in the lung and was directly dependent on IL-4 signaling. These results demonstrate that IL-4 during helminth infection can non-specifically condition CD8 + T cells, leading to a subsequently raised antigen-specific CD8 + T cell activation that enhances control of viral infection.
Databáze: MEDLINE
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