Plant-feeding phlebotomine sand flies, vectors of leishmaniasis, prefer Cannabis sativa .

Autor:	Abbasi I; Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, The Kuvin Centre for the Study of Infectious and Tropical Diseases, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel., Trancoso Lopo de Queiroz A; Instituto Gonçalo Moniz-Fiocruz Bahia, 40296-710 Salvador, Bahia, Brazil., Kirstein OD; Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, The Kuvin Centre for the Study of Infectious and Tropical Diseases, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel., Nasereddin A; Genomics Applications Laboratory, Core Research Facility, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel., Horwitz BZ; Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, The Kuvin Centre for the Study of Infectious and Tropical Diseases, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel., Hailu A; College of Health Sciences, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Salah I; Mitrani Department of Desert Ecology, Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion 84990, Israel., Mota TF; Instituto Gonçalo Moniz-Fiocruz Bahia, 40296-710 Salvador, Bahia, Brazil., Fraga DBM; Instituto Gonçalo Moniz-Fiocruz Bahia, 40296-710 Salvador, Bahia, Brazil., Veras PST; Instituto Gonçalo Moniz-Fiocruz Bahia, 40296-710 Salvador, Bahia, Brazil., Poche D; Genesis Laboratories, Inc., Wellington, CO 80549., Poche R; Genesis Laboratories, Inc., Wellington, CO 80549., Yeszhanov A; M. Aikimbayev Kazakh Scientific Center of Quarantine and Zoonotic Diseases, A35P0K3 Almaty, Kazakhstan., Brodskyn C; Instituto Gonçalo Moniz-Fiocruz Bahia, 40296-710 Salvador, Bahia, Brazil., Torres-Poche Z; Genesis Laboratories, Inc., Wellington, CO 80549., Warburg A; Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, The Kuvin Centre for the Study of Infectious and Tropical Diseases, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel; alonw@ekmd.huji.ac.il.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Nov 13; Vol. 115 (46), pp. 11790-11795. Date of Electronic Publication: 2018 Oct 29.
DOI:	10.1073/pnas.1810435115
Abstrakt:	Blood-sucking phlebotomine sand flies (Diptera: Psychodidae) transmit leishmaniasis as well as arboviral diseases and bartonellosis. Sand fly females become infected with Leishmania parasites and transmit them while imbibing vertebrates' blood, required as a source of protein for maturation of eggs. In addition, both females and males consume plant-derived sugar meals as a source of energy. Plant meals may comprise sugary solutions such as nectar or honeydew (secreted by plant-sucking homopteran insects), as well as phloem sap that sand flies obtain by piercing leaves and stems with their needle-like mouthparts. Hence, the structure of plant communities can influence the distribution and epidemiology of leishmaniasis. We designed a next-generation sequencing (NGS)-based assay for determining the source of sand fly plant meals, based upon the chloroplast DNA gene ribulose bisphosphate carboxylase large chain ( rbcL ). Here, we report on the predilection of several sand fly species, vectors of leishmaniasis in different parts of the world, for feeding on Cannabis sativa We infer this preference based on the substantial percentage of sand flies that had fed on C. sativa plants despite the apparent "absence" of these plants from most of the field sites. We discuss the conceivable implications of the affinity of sand flies for C. sativa on their vectorial capacity for Leishmania and the putative exploitation of their attraction to C. sativa for the control of sand fly-borne diseases. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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