| Autor: |
Akuodor GC; Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, P. M. B. 53 Abakaliki, Nigeria, Phone: +2348036725237, E-mail:goddyakuodor@yahoo.com., Eban LK; Department of Pharmacology, College of Medical Sciences, University of Calabar, Calabar, Nigeria., Ajoku GA; Department of Medicinal Chemistry and Quality Control, National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Nigeria., Nwobodo NN; Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria., Akpan JL; Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria., Ezeokpo BC; Department of Internal Medicine, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria., Nwadike KI; Department of Pharmacology, Faculty of Medicine, University of Nigeria Enugu Campus, Enugu, Nigeria., Aja DO; Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria. |
| Abstrakt: |
Background Salacial lehmbachii stem bark is used traditionally for the treatment of diabetes mellitus and its associated complications. Treatment of diabetes is necessary to reduce these complications. Methods In this study, the antidiabetic and antihyperlipidemic potential of S. lehmbachii ethanol stem bark extract was evaluated in alloxan-induced diabetic rats at a dose of 100 mg/kg, 200 mg/kg, and 400 mg/kg p.o. daily for 21 days. Blood glucose levels, serum total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) were assessed in the animals. Results Treatment of alloxan-induced diabetic rats with S. lehmbachii stem bark extract showed significant (p<0.01) reduction in blood glucose levels when compared with diabetic control. The elevated levels of serum cholesterol, triglycerides, LDL, and VLDL were significantly (p<0.01) reduced by S. lehmbachii stem bark extract, while the level of HDL significantly (p<0.01) increased. Conclusions The results obtained suggest that S. lehmbachii stem bark extract has the potential to treat diabetes condition and hyperlipidemic disorders. |
