West Nile virus lineage 2 in Romania, 2015-2016: co-circulation and strain replacement.

Autor: Cotar AI; Cantacuzino National Medico-Military Institute for Research and Development, 103 Splaiul Independenței, 050096, Bucharest, Romania., Fălcuță E; Cantacuzino National Medico-Military Institute for Research and Development, 103 Splaiul Independenței, 050096, Bucharest, Romania., Dinu S; Cantacuzino National Medico-Military Institute for Research and Development, 103 Splaiul Independenței, 050096, Bucharest, Romania. sorind@cantacuzino.ro., Necula A; National Institute of Blood Transfusion, 2-8 Dr. C-tin Caracaş, 011155, Bucharest, Romania., Bîrluțiu V; Faculty of Medicine, Lucian Blaga University, 2A Lucian Blaga, 550169, Sibiu, Romania.; Academic Emergency Hospital, 2-4 Corneliu Coposu Boulevard, 550245, Sibiu, Romania., Ceianu CS; Cantacuzino National Medico-Military Institute for Research and Development, 103 Splaiul Independenței, 050096, Bucharest, Romania., Prioteasa FL; Cantacuzino National Medico-Military Institute for Research and Development, 103 Splaiul Independenței, 050096, Bucharest, Romania.
Jazyk: angličtina
Zdroj: Parasites & vectors [Parasit Vectors] 2018 Oct 26; Vol. 11 (1), pp. 562. Date of Electronic Publication: 2018 Oct 26.
DOI: 10.1186/s13071-018-3145-5
Abstrakt: Background: West Nile virus (WNV) is endemic in southeastern Romania and, after the unprecedented urban epidemic in Bucharest in 1996 caused by lineage 1 WNV, cases of West Nile fever have been recorded every year. Furthermore, a new outbreak occurred in 2010, this time produced by a lineage 2 WNV belonging to the Eastern European clade (Volgograd 2007-like strain), which was detected in humans and mosquitoes in the following years.
Results: We report here, for the first time, the emergence, in 2015, of lineage 2 WNV belonging to the monophyletic Central/Southern European group of strains which replaced in 2016, the previously endemized lineage 2 WNV Volgograd 2007-like strain in mosquito populations. The emerged WNV strain harbors H249P (NS3 protein) and I159T (E glycoprotein) substitutions, which have been previously associated in other studies with neurovirulence and efficient vector transmission.
Conclusions: In 2016, both early amplification of the emerged WNV and complete replacement in mosquito populations of the previously endemized WNV occurred in southeastern Romania. These events were associated with a significant outbreak of severe West Nile neuroinvasive disease in humans.
Databáze: MEDLINE
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