| Autor: |
Larsson SC; Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden. susanna.larsson@ki.se., Traylor M; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB20QQ, UK. mt628@medschl.cam.ac.uk., Markus HS; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB20QQ, UK. hsm32@medschl.cam.ac.uk. |
| Jazyk: |
angličtina |
| Zdroj: |
Nutrients [Nutrients] 2018 Oct 25; Vol. 10 (11). Date of Electronic Publication: 2018 Oct 25. |
| DOI: |
10.3390/nu10111575 |
| Abstrakt: |
Vitamin K plays a crucial role in blood coagulation, and hypercoagulability has been linked to atherosclerosis-related vascular disease. We used the Mendelian randomization study design to examine whether circulating vitamin K₁ (phylloquinone) levels are associated with ischemic stroke. Four single-nucleotide polymorphisms associated with vitamin K₁ levels were used as instrumental variables. Summary-level data for large artery atherosclerotic stroke ( n = 4373 cases), small vessel stroke ( n = 5386 cases), cardioembolic stroke ( n = 7193 cases), and any ischemic stroke ( n = 34,217 cases and 404,630 non-cases) were available from the MEGASTROKE consortium. Genetically-predicted circulating vitamin K₁ levels were associated with large artery atherosclerotic stroke but not with any other subtypes or ischemic stroke as a whole. The odds ratios per genetically predicted one nmol/L increase in natural log-transformed vitamin K₁ levels were 1.31 (95% confidence interval (CI) 1.12⁻1.53; p = 7.0 × 10 -4 ) for large artery atherosclerotic stroke, 0.98 (95% CI 0.85⁻1.12; p = 0.73) for small vessel stroke, 1.01 (95% CI 0.90⁻1.14; p = 0.84) for cardioembolic stroke, and 1.05 (95% CI 0.99⁻1.11; p = 0.11) for any ischemic stroke. These findings indicate that genetic predisposition to higher circulating vitamin K₁ levels is associated with an increased risk of large artery atherosclerotic stroke. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
