Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence.

Autor:	Cavalcante JR; Departamento de Cirurgia e Maternidade Escola Assis Chateaubriand, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Pinheiro LGP; Departamento de Cirurgia e Maternidade Escola Assis Chateaubriand, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Almeida PRC; Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Ferreira MVP; Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Cruz GA; Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Campelo TA; Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Silva CS; Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Lima LNGC; Instituto Evandro Chagas, Belem, PA, BR., Oliveira BMK; Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Lima LM; Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Feitosa LMC; Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Pinheiro AC; Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR., Frota CC; Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR.
Jazyk:	angličtina
Zdroj:	Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2018 Oct 18; Vol. 73, pp. e465. Date of Electronic Publication: 2018 Oct 18.
DOI:	10.6061/clinics/2018/e465
Abstrakt:	Objective: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. Method: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region. Results: Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples. Conclusions: The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu