Iron in Restless Legs Syndrome.
| Autor: | Schulte EC; Neurologische Klinik und Poliklinik Klinikum rechts der Isar Technische Universität München Munich Germany.; Institut für Humangenetik Helmholtz Zentrum München Munich Germany.; Institut für Humangenetik Klinikum rechts der Isar Technische Universität München Munich Germany., Kaffe M; Neurologische Klinik und Poliklinik Klinikum rechts der Isar Technische Universität München Munich Germany.; Institut für Humangenetik Klinikum rechts der Isar Technische Universität München Munich Germany., Schormair B; Institut für Humangenetik Helmholtz Zentrum München Munich Germany.; Institut für Humangenetik Klinikum rechts der Isar Technische Universität München Munich Germany., Winkelmann J; Neurologische Klinik und Poliklinik Klinikum rechts der Isar Technische Universität München Munich Germany.; Institut für Humangenetik Helmholtz Zentrum München Munich Germany.; Institut für Humangenetik Klinikum rechts der Isar Technische Universität München Munich Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Movement disorders clinical practice [Mov Disord Clin Pract] 2014 Jun 12; Vol. 1 (3), pp. 161-172. Date of Electronic Publication: 2014 Jun 12 (Print Publication: 2014). |
| DOI: | 10.1002/mdc3.12047 |
| Abstrakt: | A link between restless legs syndrome (RLS) and iron has been recognized for several decades. Yet, the precise role that iron or other components of iron metabolism play in bringing about RLS is still a matter of debate. During the last few years, many new pieces of evidence from genetics, pathology, imaging, and clinical studies have surfaced. However, the way this evidence fits into the larger picture of RLS as a disease is not always easily understood. To provide a better understanding of the complex interplay between iron metabolism and RLS and highlight areas that need further elucidation, we systematically and critically review the current literature on the role of iron in RLS pathophysiology and treatment with a special emphasis on genetics, neuropathology, cell and animal models, imaging studies, and therapy. |
| Databáze: | MEDLINE |
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