| Autor: |
Rigby HB; Parkinson's Disease and Movement Disorders Center Department of Neurology Mayo Clinic Scottsdale Arizona USA., Dugger BN; Civin Laboratory for Neuropathology Banner Sun Health Research Institute Sun City Arizona USA., Hentz JG; Department of Biostatistics Mayo Clinic Scottsdale Arizona USA., Adler CH; Parkinson's Disease and Movement Disorders Center Department of Neurology Mayo Clinic Scottsdale Arizona USA., Beach TG; Civin Laboratory for Neuropathology Banner Sun Health Research Institute Sun City Arizona USA., Shill HA; Cleo Roberts Center Banner Sun Health Research Institute Sun City Arizona USA.; University of Arizona College of Medicine Phoenix Arizona USA., Driver-Dunckley E; Parkinson's Disease and Movement Disorders Center Department of Neurology Mayo Clinic Scottsdale Arizona USA., Sabbagh MN; Cleo Roberts Center Banner Sun Health Research Institute Sun City Arizona USA.; University of Arizona College of Medicine Phoenix Arizona USA., Sue LI; Civin Laboratory for Neuropathology Banner Sun Health Research Institute Sun City Arizona USA., Caviness JN; Parkinson's Disease and Movement Disorders Center Department of Neurology Mayo Clinic Scottsdale Arizona USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Movement disorders clinical practice [Mov Disord Clin Pract] 2014 Oct 29; Vol. 2 (1), pp. 33-38. Date of Electronic Publication: 2014 Oct 29 (Print Publication: 2015). |
| DOI: |
10.1002/mdc3.12104 |
| Abstrakt: |
The pathologic changes of Parkinson's disease (PD) and Progressive Supranuclear Palsy (PSP) have been reported to coexist, but whether PSP pathology modifies the clinical course of those individuals is unknown. The aim of this study was to determine whether clinical features of pathologically confirmed PD subjects with concomitant PSP pathology differ from those with PD alone. Subjects enrolled in the Arizona Study of Aging and Neurodegenerative Disorders had annual movement and cognitive evaluations from enrollment until death/autopsy. All cases between 1997 and 2014 with a final clinicopathological diagnosis of PD with or without PSP at autopsy were analyzed. Overall, 12 of the 125 cases with pathologically confirmed PD had coexisting PSP pathology (9.6%). Those with PD-PSP had more-prominent postural instability, body bradykinesia, difficulty arising from a chair, and falls; asymmetric onset was less common in this group. Downgaze palsy and square wave jerks were infrequent in both groups. Gender, age at death, disease duration, rate of dementia, and presence of rest tremor did not differ between groups. Only 58% of subjects in the PD-PSP group were correctly given a final diagnosis in life of PD, compared to 91% of those with PD alone. The combination of PD and PSP pathology yields a heterogeneous clinical syndrome that often resembles PD, but may be more symmetric at onset and have more-prominent postural instability and falls. Our observations suggest that coexisting PSP pathology may be an important factor contributing to the clinical heterogeneity in PD and a potential confounder in diagnosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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