Bisleuconothines B-D, Modified Eburnane-Aspidosperma Bisindole Alkaloids from Leuconotis griffithii.

Autor:	Nugroho AE; Hoshi University Faculty of Pharmaceutical Sciences , Hoshi University , Shinagawa, Tokyo 142-8501 , Japan., Zhang W; Hoshi University Faculty of Pharmaceutical Sciences , Hoshi University , Shinagawa, Tokyo 142-8501 , Japan., Hirasawa Y; Hoshi University Faculty of Pharmaceutical Sciences , Hoshi University , Shinagawa, Tokyo 142-8501 , Japan., Tang Y; Hoshi University Faculty of Pharmaceutical Sciences , Hoshi University , Shinagawa, Tokyo 142-8501 , Japan., Wong CP; Hoshi University Faculty of Pharmaceutical Sciences , Hoshi University , Shinagawa, Tokyo 142-8501 , Japan., Kaneda T; Hoshi University Faculty of Pharmaceutical Sciences , Hoshi University , Shinagawa, Tokyo 142-8501 , Japan., Hadi AHA; Department of Chemistry, Faculty of Science , University Malaya , 50603 Kuala Lumpur , Malaysia., Morita H; Hoshi University Faculty of Pharmaceutical Sciences , Hoshi University , Shinagawa, Tokyo 142-8501 , Japan.
Jazyk:	angličtina
Zdroj:	Journal of natural products [J Nat Prod] 2018 Nov 26; Vol. 81 (11), pp. 2600-2604. Date of Electronic Publication: 2018 Oct 26.
DOI:	10.1021/acs.jnatprod.8b00749
Abstrakt:	Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10' and C-2-O-C-9'. All compounds were deemed noncytotoxic (IC 50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.
Databáze:	MEDLINE
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