[Arterial Hypertension and Methylenetetrahydrofolate Reductase C677T Gene Polymorphism].

Autor:	Pavlova OS; Republican Science and Practice Center 'Cardiology '., Ogurtsova SE; Institute of Bioorganic Chemistry., Liventseva MM; Republican Science and Practice Center 'Cardiology '., Korobko IY; Republican Science and Practice Center 'Cardiology '., Mrochek AG; Republican Science and Practice Center 'Cardiology '.
Jazyk:	ruština
Zdroj:	Kardiologiia [Kardiologiia] 2018 Oct (10), pp. 5-11.
Abstrakt:	Objective: to determine the association of polymorphisms of C677T methylenetetrahydrofolate reductase (MTHFR) gene with essential arterial hypertension (EH) in the group of patients of Belarusian ethnicity. Methods: The clinical examination and molecular genetic study of the polymorphism C677T of MTHFR gene by polymerase chain reaction and restriction fragment length polymorphism analysis were performed in 423 people, including 315 patients with EH and 108 healthy individuals. Results: The distribution of C and T alleles of polymorphism C677T of the MTHFR gene in hypertensive patients was 67.8 and 32.2%, in normotensive individuals - 71.8 and 28.2%, respectively. In the group of hypertensive patients, the prevalence of the TT (C677T) genotype of the MTHFR gene was 10.8%, in the healthy group - 5.5%. The TT genotype of the C677T MTHFR gene was more common in hypertensive patients with obesity in comparison with hypertensive patients with body mass index < 29.9 kg/m2 (61.8 vs 38.2%, respectively; p.
Databáze:	MEDLINE
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