Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions.

Autor:	Albert C; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Huang N; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Tsapis N; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Geiger S; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France.; Laboratoire Structures, Propriétés et Modélisation des Solides (SPMS) UMR CNRS 8580, CentraleSupélec, Université Paris-Saclay , 3 Rue Joliot Curie , 91190 Gif-sur-Yvette , France., Rosilio V; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Mekhloufi G; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Chapron D; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Robin B; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Beladjine M; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Nicolas V; Plateforme d'imagerie cellulaire MIPSIT, SFR-UMS-IPSIT, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Fattal E; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France., Agnely F; Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue J.B. Clément , F-92296 Châtenay-Malabry , France.
Jazyk:	angličtina
Zdroj:	Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2018 Nov 20; Vol. 34 (46), pp. 13935-13945. Date of Electronic Publication: 2018 Nov 05.
DOI:	10.1021/acs.langmuir.8b02558
Abstrakt:	Pickering emulsions were formulated using biodegradable and biocompatible poly(lactic- co-glycolic acid) (PLGA) nanoparticles (NPs) prepared without surfactants or any other polymer than PLGA. A pharmaceutical and cosmetic oil (Miglyol) was chosen as the oil phase at a ratio of 10% w/w. These emulsions were then compared with emulsions using the same oil but formulated with well-described PLGA-poly(vinyl alcohol) (PVA) NPs, i.e., with PVA as NP stabilizers. Strikingly, the emulsions demonstrated very different structures at macroscopic, microscopic, and interfacial scales, depending on the type of NPs used. Indeed, the emulsion layer was significantly thicker when using PLGA NPs rather than PLGA-PVA NPs. This was attributed to the formation and coexistence of multiple water-in-oil-in-water (W/O/W) and simple oil-in-water (O/W) droplets, using a single step of emulsification, whereas simple O/W emulsions were obtained with PLGA-PVA NPs. The latter NPs were more hydrophilic than bare PLGA NPs because of the presence of PVA at their surface. Moreover, PLGA NPs only slightly lowered the oil/water interfacial tension whereas the decrease was more pronounced with PLGA-PVA NPs. The PVA chains at the PLGA-PVA NP surface could probably partially desorb from the NPs and adsorb at the interface, inducing the interfacial tension decrease. Finally, independent of their composition, NPs were adsorbed at the oil/water interface without influencing its rheological behavior, possibly due to their mobility at their interface. This work has direct implications in the formulation of Pickering emulsions and stresses the paramount influence of the physicochemical nature of the NP surface into the stabilization of these systems.
Databáze:	MEDLINE
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