Using reflectance confocal microscopy to observe in vivo melanolysis after treatment with the picosecond alexandrite laser and Q-switched Nd:YAG laser in melasma.

Autor: Jo DJ; Dermapro Skin Research Center, Dermapro Ltd., Seoul, Korea., Kang IH; Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea., Baek JH; Dermapro Skin Research Center, Dermapro Ltd., Seoul, Korea., Gwak MJ; Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea., Lee SJ; Arumdaun Nara Dermatologic Clinic, Seoul, Korea., Shin MK; Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
Jazyk: angličtina
Zdroj: Lasers in surgery and medicine [Lasers Surg Med] 2019 Jul; Vol. 51 (5), pp. 423-429. Date of Electronic Publication: 2018 Oct 23.
DOI: 10.1002/lsm.23025
Abstrakt: Objectives: Melasma is an acquired type of hyperpigmentation that is characterized by the appearance of scattered light- to dark-brown macules and patches on the face. Recently, several lasers have been proposed as treatment options for melasma. In particular, the picosecond alexandrite laser is an ideal laser for selective photothermal melanolysis. The aim of our study was to compare the effectiveness in melanolysis of a single treatment of the picosecond alexandrite laser with that of the Q-switched Nd:YAG laser using reflectance confocal microscopy imaging of the melasma lesions.
Materials and Methods: We performed a spilt-face study using the picosecond alexandrite laser and Q-switched Nd:YAG laser in eight patients with melasma. Both melasma lesions and surrounding normal skin were examined under reflectance confocal microscopy 1 and 24 hours after treatment. The melanin intensity of each skin layer was investigated.
Results: At baseline, melasma has irregular melanin distribution and a higher melanin density than surrounding normal skin under reflectance confocal microscopy. After a single treatment with either the picosecond alexandrite laser or the Q-switched Nd:YAG laser, both melanin-induced reflectance and melanin index decreased.
Conclusion: Our findings suggest that it is feasible to assess the distribution of melanin by reflectance confocal microscopy and observe the melanolysis in melasma lesion after laser treatment. Lasers Surg. Med. 51:423-429, 2019. © 2018 Wiley Periodicals, Inc.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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