Correlation between pancreatic mast cells and the low grade inflammation in adipose tissue of experimental prediabetes.

Autor: Abdel-Hamid AAM; Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt. Electronic address: profahmadpasha@mans.edu.eg., Firgany AEL; Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt; Department of Basic Medical Science, Horus University, Egypt.
Jazyk: angličtina
Zdroj: Acta histochemica [Acta Histochem] 2019 Jan; Vol. 121 (1), pp. 35-42. Date of Electronic Publication: 2018 Oct 19.
DOI: 10.1016/j.acthis.2018.10.005
Abstrakt: The role of mast cells (MCs) in prediabetes (Pre-DM) is not clearly elucidated. In the current study rats (n = 22 each) were divided equally into; control and Pre-DM (received high fat diet, HFD) groups. Samples from pancreas as well as from visceral adipose tissue (VAT) were studied for the consequent changes. We detected a significantly increased mast cell count (MCC) in the pancreas of Pre-DM compared to that of control. Frequent degranulation of MC granules was observed in Pre-DM. VAT of the Pre-DM had significantly increased (p < 0.05) macrophages (CD68 + ) and mast cells (tryptase + ) compared to that of the control. A significant increase (p < 0.05) in CD68 mRNA expression as well as in the level of IL-1 β, IL-6, TNF-α and TGF- β1 was detected in VAT of Pre-DM with a significant positive correlation (p < 0.05) with the MCC. All these findings may indicate a potential role of MC in the low grade inflammation of VAT in Pre-DM.
(Copyright © 2018 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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