Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle.

Autor: Heo JW; Department of Kinesiology, Inha University, Incheon 22212, Korea. gjwnsdnjs03@naver.com., Yoo SZ; Department of Kinesiology, Inha University, Incheon 22212, Korea. susie_737@naver.com., No MH; Department of Kinesiology, Inha University, Incheon 22212, Korea. 77nodaji@hanmail.net., Park DH; Department of Kinesiology, Inha University, Incheon 22212, Korea. dparkosu@inha.ac.kr., Kang JH; Department of Pharmacology and Medicinal Toxicology Research Center, Inha University School of Medicine, Incheon 22212, Korea. johykang@inha.ac.kr., Kim TW; Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea. twkim0806@naver.com., Kim CJ; Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea. changju@khu.ac.kr., Seo DY; National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea. sdy925@gmail.com., Han J; National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea. phyhanj@gmail.com., Yoon JH; Department of Kinesiology, Hannam University, Daejeon 34430, Korea. yoonjh@hannam.ac.kr., Jung SJ; Department of Leisure Sports, Seoil University, Seoul 02192, Korea. sujeenj@nate.com., Kwak HB; Department of Kinesiology, Inha University, Incheon 22212, Korea. kwakhb@inha.ac.kr.
Jazyk: angličtina
Zdroj: International journal of environmental research and public health [Int J Environ Res Public Health] 2018 Oct 19; Vol. 15 (10). Date of Electronic Publication: 2018 Oct 19.
DOI: 10.3390/ijerph15102301
Abstrakt: Obesity is characterized by the induction of skeletal muscle remodeling and mitochondria-mediated apoptosis. Exercise has been reported as a positive regulator of skeletal muscle remodeling and apoptosis. However, the effects of exercise on skeletal muscle remodeling and mitochondria-mediated apoptosis in obese skeletal muscles have not been clearly elucidated. Four-week-old C57BL/6 mice were randomly assigned into four groups: control (CON), control plus exercise (CON + EX), high-fat diet (HFD), and HFD plus exercise groups (HFD + EX). After obesity was induced by 20 weeks of 60% HFD feeding, treadmill exercise was performed for 12 weeks. Exercise ameliorated the obesity-induced increase in extramyocyte space and a decrease in the cross-sectional area of the skeletal muscle. In addition, it protected against increases in mitochondria-mediated apoptosis in obese skeletal muscles. These results suggest that exercise as a protective intervention plays an important role in regulating skeletal muscle structure and apoptosis in obese skeletal muscles.
Databáze: MEDLINE
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