| Autor: |
Bermejo-Velasco D; Translational Chemical Biology Laboratory, Division of Polymer Chemistry, Department of Chemistry-Ångstrom, Uppsala University, Uppsala, Sweden. oommen.varghese@kemi.uu.se., Nawale GN, Oommen OP, Hilborn J, Varghese OP |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2018 Nov 01; Vol. 54 (88), pp. 12507-12510. |
| DOI: |
10.1039/c8cc05405c |
| Abstrakt: |
We describe the fast reaction kinetics between 1,2-aminothiols and aldehydes. Under physiological conditions such a click-type reaction afforded a thiazolidine product that remains stable and did not require any catalyst. This type of bioorthogonal reaction offers enormous potential for the coupling of biomolecules in an efficient and biocompatible manner. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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