Prevalence of enteric parasitic infections among people living with HIV in Abeokuta, Nigeria.

Autor: Amoo JK; Department of Medical Microbiology & Parasitology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria., Akindele AA; Department of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, Osogbo, Nigeria., Amoo AOJ; Department of Medical Microbiology & Parasitology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria., Efunshile AM; Department of Medical Microbiology & Parasitology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria.; Department of Medical Microbiology, Ebonyi State University, Abakaliki, Nigeria., Ojurongbe TA; Department of Mathematical and Physical Sciences, Osun State University, Osogbo, Nigeria., Fayemiwo SA; Department of Medical Microbiology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Thomas BN; Department of Biomedical Sciences, College of Health Sciences and Technology, Rochester Institute of Technology, Rochester NY, USA., Ojurongbe O; Department of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, Osogbo, Nigeria.
Jazyk: angličtina
Zdroj: The Pan African medical journal [Pan Afr Med J] 2018 May 28; Vol. 30, pp. 66. Date of Electronic Publication: 2018 May 28 (Print Publication: 2018).
DOI: 10.11604/pamj.2018.30.66.13160
Abstrakt: Introduction: Enteric parasitic infections have been increasingly recognized as etiology of life-threatening chronic diarrhea in PLWHA in sub-Saharan Africa. This study investigated the prevalence and burden of intestinal parasitic infection among PLWHA in Abeokuta, southwest Nigeria.
Methods: Freshly passed stool samples were collected from PLWHA. Detection of Cryptosporidium spp and Microsporidium spp was carried out with Kinyoun's stain and Weber's Chromotrope-based stain respectively. Investigation of other intestinal parasites was done using the direct saline preparation and formol-ether concentration methods. CD4+ T cell count was measured using Partec flow cytometry technique.
Results: A total of 231 (males: females 96:135; mean age 31.81±11.40 years) PLWHA were recruited into the study, among whom 84 (36.4%) were infected with at least one intestinal parasites. Fifty two (22.5%) individuals were positive for Cryptosporidium spp and a significant association between Cryptosporidium spp and diarrhea was observed (p=0.006). Seven (3.0%) were positive for Microsporidium spp. Helminths recovered included Ascaris lumbricoides (20.8%), hookworm (6.5%), Strongyloides stercoralis (4.3%), Trichuris trichiura (5.6%) and Taenia spp. (5.6%). Cryptosporidium spp , Microsporidium spp and S. stercoralis were significantly associated with CD4+ count ≥ 200 cells/mm 3 (p<0.05). Cryptosporidium spp and A. lumbricoides were significantly observed among patients that are anti-retroviral therapy (ART) naive.
Conclusion: High prevalence of opportunistic parasitic infection was significantly correlated with diarrhea, low CD4+ count and ART naïve individuals in the study. These findings re-emphasize the need for early diagnosis of opportunistic parasites and appropriate intervention among PLWHA.
Competing Interests: The authors declare no competing interests.
Databáze: MEDLINE
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