The role of sentinel lymph node biopsy in early-stage cervical cancer: A systematic review.

Autor:	Cheng-Yen Lai J; Department of Medical Research, Taitung MacKay Memorial Hospital, Taitung, Taiwan., Yang MS; Department of Radiology, Taitung MacKay Memorial Hospital, Taitung, Taiwan., Lu KW; Department of Radiation Oncology, Taitung MacKay Memorial Hospital, Taitung, Taiwan., Yu L; Department of Radiation Oncology, Taitung MacKay Memorial Hospital, Taitung, Taiwan., Liou WZ; Department of Radiology, Taitung MacKay Memorial Hospital, Taitung, Taiwan., Wang KL; Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Nursing, MacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan; Department of Obstetrics and Gynecology, Taitung MacKay Memorial Hospital, Taitung, Taiwan; Department of Obstetrics and Gynecology, MacKay Medical College, New Taipei City, Taiwan. Electronic address: KL421229@ms6.hinet.net.
Jazyk:	angličtina
Zdroj:	Taiwanese journal of obstetrics & gynecology [Taiwan J Obstet Gynecol] 2018 Oct; Vol. 57 (5), pp. 627-635.
DOI:	10.1016/j.tjog.2018.08.003
Abstrakt:	Pelvic lymphadenectomy procedure is included as part of the standard protocol of radical hysterectomy for women with early-stage cervical cancer (Stage IA to IB1). However, an important sequel to lymphadenectomy procedure is the possible occurrence of lymphedema in the lower abdomen and lower extremities. Previous researches also find that women with lymphedema experience many emotional impacts, including depression, anxiety, and adjustment problems. Only approximately 10% of women with clinical stage IB cervical carcinoma were involved with metastatic disease. If we could better define the relevant lymphatic nodes that must be removed, it is then possible to limit routinely performed lymphadenectomy for regional nodal metastasis in the pelvis, and hence reduce the need for extended surgical staging (para-aortic lymphadenectomy). We systematically reviewed a body of literature and updated available information concerning the current progress on the application of sentinel lymph node biopsy in women with early-stage cervical cancer. All detection methods (preoperative injection of radiocolloid tracer, intraoperative injection of blue dye, or a combination of both techniques) demonstrated reasonable sensitivity (with a few exceptions), high specificity, low false-negative rate and high negative predictive value. The review of the literature in this paper should convince the readers that sentinel lymph node biopsy has the potential to improve the quality of life and the possibility to maintain relapse-free survival for women with cervical cancer. The proper identification of negative sentinel lymph node allows individualized therapy and may preclude the need of lymphadenectomy procedure in most of these women. (Copyright © 2018. Published by Elsevier B.V.)
Databáze:	MEDLINE
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