Are cord blood visfatin concentrations different depending on birth weight category?

Autor: Estrada-Zúñiga CM; Department of Pediatrics, University Hospital 'Dr. José Eleuterio González' Universidad Autónoma de Nuevo León, Monterrey, Mexico., de la O-Cavazos ME; Department of Pediatrics, University Hospital 'Dr. José Eleuterio González' Universidad Autónoma de Nuevo León, Monterrey, Mexico., Mancillas-Adame L; Division of Endocrinology, Internal Medicine Department, University Hospital 'Dr. José Eleuterio González' Universidad Autónoma de Nuevo León, Monterrey, Mexico., Lavalle-González FJ; Division of Endocrinology, Internal Medicine Department, University Hospital 'Dr. José Eleuterio González' Universidad Autónoma de Nuevo León, Monterrey, Mexico., Lavalle-Cantú AL; Department of Pediatrics, University Hospital 'Dr. José Eleuterio González' Universidad Autónoma de Nuevo León, Monterrey, Mexico., Villarreal-Pérez JZ; Division of Endocrinology, Internal Medicine Department, University Hospital 'Dr. José Eleuterio González' Universidad Autónoma de Nuevo León, Monterrey, Mexico., Treviño-Garza C; Department of Pediatrics, University Hospital 'Dr. José Eleuterio González' Universidad Autónoma de Nuevo León, Monterrey, Mexico. Electronic address: cotrevin@hotmail.com.
Jazyk: English; Spanish; Castilian
Zdroj: Endocrinologia, diabetes y nutricion [Endocrinol Diabetes Nutr (Engl Ed)] 2019 Jan; Vol. 66 (1), pp. 35-40. Date of Electronic Publication: 2018 Oct 16.
DOI: 10.1016/j.endinu.2018.07.004
Abstrakt: Background and Objective: Increased visceral adipose tissue mass is strongly associated to metabolic disorders. Visfatin is a visceral fat adipocytokine. There is epidemiological evidence of a link between a suboptimal gestational environment and a greater propensity to develop metabolic disease in adult life. The objective of this study was to establish whether visfatin concentrations in umbilical cord blood are different in newborns small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA).
Subjects and Methods: Term newborns from an university medical center were included in the study. A blood sample was taken from the umbilical cord vein of each baby immediately after birth. Visfatin was measured using an enzyme immunoassay in the study population, consisting of 35 subjects in the SGA group, 58 in the AGA group, and 35 in the LGA group.
Results: Cord blood visfatin concentrations were not different in the three groups, with respective values of 2.78 (1.86-4.49) ng/mL, 3.28 (1.98-4.97) ng/mL, and 3.46 (2.48-5.38) ng/mL in the SGA, AGA and LGA groups (p=0.141). Gestational weight gain (GWG) (14.09±6.37kg) was negatively associated to visfatin levels (r=-0.218, p=0.036). GWG is an independent predictor of visfatin concentrations (r 2 =-0.067, p=0.027).
Conclusions: There were no differences in cord blood visfatin concentrations depending on birth weight. GWG is an independent predictor of visfatin levels in the cord blood of term newborns.
(Copyright © 2018 SEEN y SED. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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