Perivascular Tumor-Infiltrating Leukocyte Scoring for Prognosis of Resected Hepatocellular Carcinoma Patients.

Autor:	Schoenberg MB; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. markus.schoenberg@med.uni-muenchen.de., Hao J; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. haojc416@gmail.com.; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610513, China. haojc416@gmail.com., Bucher JN; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. julian.bucher@med.uni-muenchen.de., Miksch RC; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. rainer.miksch@med.uni-muenchen.de., Anger HJW; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. hubertusanger@gmail.com., Mayer B; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. barbara.mayer@med.uni-muenchen.de., Mayerle J; Department of Medicine II, University Hospital, Ludwig-Maximilians-Universität Munich, Marchioninistraße 15, 81377 Munich, Germany. Julia.mayerle@med.uni-muenchen.de., Neumann J; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. jens.neumann@med.uni-muenchen.de., Guba MO; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. markus.guba@med.uni-muenchen.de.; Transplantation Center Munich, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. markus.guba@med.uni-muenchen.de., Werner J; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. jens.werner@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich, Pettenkoferstraße 8a, 80336 Munich, Germany. jens.werner@med.uni-muenchen.de., Bazhin AV; Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany. alexandr.bazhin@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich, Pettenkoferstraße 8a, 80336 Munich, Germany. alexandr.bazhin@med.uni-muenchen.de.
Jazyk:	angličtina
Zdroj:	Cancers [Cancers (Basel)] 2018 Oct 18; Vol. 10 (10). Date of Electronic Publication: 2018 Oct 18.
DOI:	10.3390/cancers10100389
Abstrakt:	Liver resection is a curative treatment for hepatocellular carcinoma (HCC). Tumor-infiltrating leukocytes (TILs) are important players in predicting HCC recurrence. However, the invasive margin could not be confirmed as relevant for HCC. The migration of immune cells into HCC may originate from intratumoral vessels. No previous study has examined perivascular (PV) infiltration. Tumors from 60 patients were examined. Immunohistochemistry was performed against CD3, CD8, CD20, and CD66b. TILs were counted in the PV regions using an algorithm for quantification of the tumor immune stroma (QTiS). The results were correlated with overall (OS) and disease-free survival (DFS), clinical parameters, and laboratory values. PV infiltration of TILs was predominant in resected HCC. Higher PV infiltration of CD3⁺ ( p = 0.016) and CD8⁺ ( p = 0.028) independently predicted better OS and DFS, respectively. CD20⁺ showed a trend towards better DFS ( p = 0.076). Scoring of CD3⁺, CD8⁺, and CD20⁺ independently predicted OS and DFS ( p < 0.01). The amount of perivascular-infiltrating CD3⁺ cells is an independent predictor of better OS, and CD8⁺ cells independently predict prolonged DFS. Our novel perivascular infiltration scoring (PVIS) can independently predict both DFS and OS in resected HCC patients.
Databáze:	MEDLINE
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