Prevalence of HIV in Patients with Malignancy and of Malignancy in HIV Patients in a Tertiary Care Center from North India.

Autor:	Sinha S; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Agarwal A; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Gupta K; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Mandal D; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Jain M; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Detels R; Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, United States., Nandy K; Department of Biostatistics and Epidemiology, School of Public Health, University of North Texas Health Science Center, United States., DeVos MA; Department of Biostatistics and Epidemiology, School of Public Health, University of North Texas Health Science Center, United States., Sharma SK; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Manoharan N; Department of Radiation Oncology, Dr. BRA IRCH, All India Institute of Medical Sciences, New Delhi, India., Julka PK; Department of Radiation Oncology, Dr. BRA IRCH, All India Institute of Medical Sciences, New Delhi, India., Rath GK; Department of Radiation Oncology, Dr. BRA IRCH, All India Institute of Medical Sciences, New Delhi, India., Ambinder RF; Division of Hematologic Malignancies, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States., Mitsuyasu RT; Department of Medicine, UCLA CARE Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Jazyk:	angličtina
Zdroj:	Current HIV research [Curr HIV Res] 2018; Vol. 16 (4), pp. 315-320.
DOI:	10.2174/1570162X16666181018161616
Abstrakt:	Background and Objectives: People living with HIV/AIDS are at an increased risk of developing cancer. The goals of this study were to obtain data on the prevalence of HIV in the cancer population and vice versa at a major tertiary cancer and HIV center in North India. Methods: This cross-sectional study was conducted over a 3-year period from July 2013 to June 2016, wherein successive HIV positive patients from an anti-retroviral therapy (ART) center were screened for malignancy. Simultaneously, successive cancer patients at the cancer center were screened for HIV. Baseline demographic details, risk factors, and laboratory investigations were obtained for all the patients. Results: Among the 999 HIV-positive patients at the ART center, the prevalence of malignancy was 2% (n=20; 95% confidence interval (CI) 1.13, 2.87). Among the 998 patients with a malignancy, the prevalence of HIV infection was 0.9% (n=9; 95% CI 0.31, 1.49). Weight loss, loss of appetite, and fever were the most common symptoms in patients with HIV and cancer. Among 29 patients with HIV and cancer, AIDS-defining cancer was found in 19 patients; non-Hodgkin's lymphoma was the most common malignancy reported (n=13). Interpretation and Conclusion: There is a low prevalence of HIV in cancer patients as well as a low prevalence of cancer in HIV patients. AIDS-defining cancers remain much more common than non-AIDS-defining cancers. With the increased coverage of ART, it is expected that non-AIDSdefining cancers will increase, as is evident from data from more developed countries. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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