Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer's Disease and CNS-Related Disorders.

Autor: Alexiou A; Novel Global Community Educational Foundation, Hebersham, Australia. alexiou@ngcef.net.; AFNP Med Austria, Haidingergasse 29, 1030, Wien, Austria. alexiou@ngcef.net., Soursou G; Medical School, Bioinformatics Program, University of Crete, Heraklion, Greece., Chatzichronis S; AFNP Med Austria, Haidingergasse 29, 1030, Wien, Austria.; Department of Informatics and Telecommunications, Bioinformatics Program, National and Kapodistrian University of Athens, Athens, Greece., Gasparatos E; Department of Psychology, City Unity College of Athens, Athens, Greece., Kamal MA; Novel Global Community Educational Foundation, Hebersham, Australia.; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.; Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia., Yarla NS; Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, 530045, India., Perveen A; School of Life Sciences, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India., Barreto GE; Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, DC, Colombia. gesbarreto@gmail.com.; Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile. gesbarreto@gmail.com., Ashraf GM; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. ashraf.gm@gmail.com.
Jazyk: angličtina
Zdroj: Molecular neurobiology [Mol Neurobiol] 2019 Jun; Vol. 56 (6), pp. 4530-4538. Date of Electronic Publication: 2018 Oct 18.
DOI: 10.1007/s12035-018-1397-x
Abstrakt: Data obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer's disease, and other central nervous system (CNS)-related disorders like the Parkinson's disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage.
Databáze: MEDLINE
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