[Relationships of rs7341475 polymorphism and DNA methylation in the reelin gene with schizophrenia symptoms].

Autor: Alfimova MV; Mental Health Research Center, Moscow, Russia., Kondratyev NV; Mental Health Research Center, Moscow, Russia., Golov AK; Mental Health Research Center, Moscow, Russia., Golubev SA; Mental Health Research Center, Moscow, Russia., Galaktionova DY; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Nasedkina TV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Golimbet VE; Mental Health Research Center, Moscow, Russia.
Jazyk: ruština
Zdroj: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2018; Vol. 118 (9), pp. 71-76.
DOI: 10.17116/jnevro201811809171
Abstrakt: Aim: To study the role of polymorphism rs7341475 and methylation of the reelin gene in symptoms of schizophrenia and semantic verbal fluency.
Material and Methods: Genotypes at the locus rs7341475 were identified in 556 patients with schizophrenic disorders. PANSS scores were obtained for 549 patients and 221 patients performed a test for semantic verbal fluency. The association of the reelin promoter methylation with the PANSS and verbal fluency measures was evaluated in 35 patients. A five-factor model of the PANSS was used.
Results: The interaction effect of sex with genotype on the PANSS scores was found (F=2.70, p=0.020). Schizophrenic men homozygous for a common allele G had the lowest scores of the positive syndrome. Verbal fluency was related to the reelin promoter methylation.
Conclusion: The results suggest that polymorphism rs7341475 may be associated with the variability of positive symptomatology in schizophrenic men. At the same time, the reelin gene methylation pattern, which consists of a higher methylation level in the region of the transcription start site and a lower one in the distal region of the promoter, may be beneficial for verbal fluency.
Databáze: MEDLINE
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