Effectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub: Cross-over trial.

Autor:	Vallejo RBB; Facultad de Enfermería, Fisioterapia y Podología., Fernandez DS; Facultad de Enfermería, Fisioterapia y Podología., Cervera LA; Facultad de Medicina. Universidad Complutense de Madrid., Aragón LM; Facultad de Enfermería, Fisioterapia y Podología., Iglesias MEL; Facultad Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid., Yurrita LRC; Facultad de Enfermería, Fisioterapia y Podología., Lopez DL; Facultad de Enfermeria y Podologia Universidade A Coruña. Spain.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2018 Oct; Vol. 97 (42), pp. e12831.
DOI:	10.1097/MD.0000000000012831
Abstrakt:	Background: Chlorhexidine and parachlorometaxylenol (PCMX) are antiseptics recommended for surgical hand antisepsis. To our knowledge, PCMX has not been evaluated for bactericidal efficacy "in vivo. Methods: We conducted a randomized, double-blind, controlled crossover trial to compare the bacterial loads on fingertips and fingernails under laboratory conditions after use of antiseptic test products, including chlorhexidine digluconate 4%, PCMX 3%, and a reference solution of propan-1-ol 60% (P-1). We assessed bacterial load after a prewash with soft soap, immediately after application of an antiseptic, and 3 hours after application and wearing of sterile, powder-free gloves. Our procedures followed those specified by European Norm (EN) 12791 for evaluating surgical hand antiseptics and using cotton swab for fingertips and fingernails. Results: Chlorhexidine digluconate 4% and PCMX 3% did not decrease bacterial load on the hands. The bactericidal performances of chlorhexidine digluconate 4% and PCMX 3% did not differ significantly. Chlorhexidine digluconate 4% and PCMX 3% increased bacterial load on the fingertips after participants had worn gloves for 3 hours. Fingernails had greater bacterial loads than skin on the fingertips. Conclusions: Chlorhexidine digluconate 4% and PCMX 3% had similar bactericidal efficacy, but they failed to meet the EN 12791 efficacy standard. Fingernails should be a particular focus of antisepsis in preparation for surgery.The trial was registered at ClinicalTrials.gov (ID: NCT02500758).
Databáze:	MEDLINE
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