| Autor: |
Gearhart-Serna LM; Department of Surgery, Division of Surgical Sciences, Duke Cancer Institute, Duke University, Durham, NC, USA.; Department of Pathology, Duke Cancer Institute, Duke University, Durham, NC, USA.; Nicholas School of the Environment, Duke Cancer Institute, Duke University, Durham, NC, USA., Jayasundara N; Nicholas School of the Environment, Duke Cancer Institute, Duke University, Durham, NC, USA.; School of Marine Sciences, University of Maine, ME, USA., Tacam M Jr; Trinity School of Arts and Sciences, Duke Cancer Institute, Duke University, Durham, NC, USA., Di Giulio R; Nicholas School of the Environment, Duke Cancer Institute, Duke University, Durham, NC, USA., Devi GR; Department of Surgery, Division of Surgical Sciences, Duke Cancer Institute, Duke University, Durham, NC, USA.; Department of Pathology, Duke Cancer Institute, Duke University, Durham, NC, USA.; Women's Cancer Program, Duke Cancer Institute, Duke University, Durham, NC, USA. |
| Abstrakt: |
Polycyclic aromatic hydrocarbon (PAH) exposure is widespread, and many PAHs are considered carcinogenic. The PAH-contaminated AWI Superfund site in Virginia provides a model for studying a complex PAH mixture and its extrapolation to cancer risk and PAH exposure in the general population. We examined cancer risk at the Superfund site due to sediment-derived PAHs and then evaluated PAH sources in the general population and potentially vulnerable subpopulations upon PAH mixture exposure. The PAH mixture was assessed for potential carcinogenicity using the US EPA's OncoLogic™ ranking tool and the US EPA list of priority PAHs. Cancer risk due to PAH exposure was calculated for Superfund site users and compared to the US EPA assessment. Human intake and health endpoints of PAHs within the mixture were extracted from USEtox® chemical fate database, while mean intake exposure was calculated for U.S. adults for select PAHs using NHANES database urinary biomarkers. Eleven PAH compounds within the mixture were of carcinogenic concern, and seven PAHs conveyed significant excess cancer risk at the Superfund site and in the general population, wherein PAH-contaminated seafood ingestion was a main contributor. Other dietary sources of PAHs derived from PAH-contaminated soil or water could also play a role in total exposure. Vulnerable populations to PAH exposure and coinciding increased cancer risk may include, in addition to smokers, children and non-Hispanic blacks, which is a public health concern. |
