| Autor: |
Romain C; Fytexia SAS, Innovation and Scientific Affairs, 34350 Vendres, France. cromain@fytexia.com., Piemontese A; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, 43126 Parma, Italy. antonio.piemontese88@gmail.com., Battista S; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, 43126 Parma, Italy. simone.battista91@gmail.com., Bernini F; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, 43126 Parma, Italy. f.bernini@unipr.it., Ossoli A; Centro E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milano, Italy. alice.ossoli@unimi.it., Strazzella A; Centro E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milano, Italy. arianna.strazzella@unimi.it., Gaillet S; Nutrition & Métabolisme, UMR 204 NUTRIPASS, Prévention des Malnutritions & des Pathologies Associées, Université Montpellier Sud de France, 34394 Montpellier, France. sylvie.gaillet-foulon@univ-montp2.fr., Rouanet JM; Nutrition & Métabolisme, UMR 204 NUTRIPASS, Prévention des Malnutritions & des Pathologies Associées, Université Montpellier Sud de France, 34394 Montpellier, France. jeanmax.rouanet@gmail.com., Cases J; Fytexia SAS, Innovation and Scientific Affairs, 34350 Vendres, France. jcases@fytexia.com., Zanotti I; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, 43126 Parma, Italy. ilaria.zanotti@unipr.it. |
| Abstrakt: |
The development of nutraceutical ingredients has risen as a nutritional solution for health prevention. This study evaluated the effects of Oleactiv ® , an ingredient developed for the prevention of atherogenesis, in hypercholesterolemic hamsters. Oleactiv ® is a polyphenol-rich ingredient obtained from artichoke, olive and grape extracts as part of fruit and vegetables commonly consumed within the Mediterranean diet. A total of 21 Golden Syrian hamsters were divided into three groups. The standard group (STD) was fed a normolipidemic diet for 12 weeks, while the control group (CTRL) and Oleactiv ® goup (OLE) were fed a high-fat diet. After sacrifice, the aortic fatty streak area (AFSA), plasmatic total cholesterol (TC), high-density lipoproteins (HDL-C), non-HDL-C and triglycerides (TG), were assessed. The cholesterol efflux capacity (CEC) of hamster plasma was quantified using a radiolabeled technique in murine macrophages J774. OLE administration induced a significant reduction of AFSA (-69%, p < 0.0001). Hamsters of the OLE group showed a significant decrease of both non-HDL-C (-173 mmol/L, p < 0.05) and TG (-154 mmol/L, p < 0.05). Interestingly, OLE induced a significant increase of total CEC (+17,33%, p < 0,05). Oleactiv ® supplementation prevented atheroma development and had positive effects on the lipid profile of hypercholesterolemic hamsters. The increased CEC underlines the anti-atherosclerotic mechanism at the root of the atheroma reduction observed. |
