| Autor: |
Muthusamy G; Department of Chemistry, Memorial University, St. John's, Newfoundland, Canada A1B 3X7. spansare@mun.ca., Pansare SV |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2018 Oct 31; Vol. 16 (42), pp. 7971-7983. |
| DOI: |
10.1039/c8ob02063a |
| Abstrakt: |
A modular, stereoselective synthesis of E-3-(arylidene)-5-(alkyl/aryl)-2(3H)-furanones was developed. The methodology features regioselective addition of β-aryl acrylic acids to iodoacetylenes to furnish the Z-acyloxy iodoalkenes. A stereoselective 5-exo-trig Mizoroki-Heck reaction of the acyloxy iodoalkenes generates the target E-2(3H)-furanones. The approach was applied in a formal synthesis of the naturally occurring kinase inhibitor BE-23372M. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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