Upper-Rim Monofunctionalisation in the Synthesis of Triazole- and Disulfide-Linked Multicalix[4]- and -[6]arenes.

Autor: Gardiner WH; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Camilleri M; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.; School of Chemistry, University of Bath, Bath, BA2 7AY, UK., Martinez-Lozano LA; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Bew SP; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Stephenson GR; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2018 Dec 17; Vol. 24 (71), pp. 19089-19097. Date of Electronic Publication: 2018 Nov 26.
DOI: 10.1002/chem.201804755
Abstrakt: Covalently linked multiple calixarenes are valued in supramolecular chemistry. This work reports an easy and versatile synthetic route to covalently linked double and triple calix[4]arene and calix[6]arenes by a novel DMF-controlled selective alkylation of a convenient and readily available upper-rim dimethylaminomethyl-substituted tetrahydroxy and hexahydroxy calix[4]arene and -[6]arenes. Synthetic routes to upper-rim functionalised redox active disulfide-linked double-, tetra- and peptidohybrid-calixarenes employing either redox chemistry (CH 2 SH) or thiolates (CH 2 S - ) are also opened up from the same key starting material.
(© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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