| Autor: |
Ng SY; Wanchi Chiropractic Clinic, Hong Kong., Bettany-Saltikov J; Institute of Health and Social Care, Teesside University, Middlesbrough, UK., Cheung IYK; Wanchi Chiropractic Clinic, Hong Kong., Chan KKY; Grace Act Chiropractic Centre Ltd., Hong Kong. |
| Jazyk: |
angličtina |
| Zdroj: |
Asian spine journal [Asian Spine J] 2018 Dec; Vol. 12 (6), pp. 1127-1145. Date of Electronic Publication: 2018 Oct 16. |
| DOI: |
10.31616/asj.2018.12.6.1127 |
| Abstrakt: |
Several theories have been proposed to explain the etiology of adolescent idiopathic scoliosis (AIS) until present. However, limited data are available regarding the impact of vitamin D insufficiency or deficiency on scoliosis. Previous studies have shown that vitamin D deficiency and insufficiency are prevalent in adolescents, including AIS patients. A series of studies conducted in Hong Kong have shown that as many as 30% of these patients have osteopenia. The 25-hydroxyvitamin D3 level has been found to positively correlate with bone mineral density (BMD) in healthy adolescents and negatively with Cobb angle in AIS patients; therefore, vitamin D deficiency is believed to play a role in AIS pathogenesis. This study attempts to review the relevant literature on AIS etiology to examine the association of vitamin D and various current theories. Our review suggested that vitamin D deficiency is associated with several current etiological theories of AIS. We postulate that vitamin D deficiency and/or insufficiency affects AIS development by its effect on the regulation of fibrosis, postural control, and BMD. Subclinical deficiency of vitamin K2, a fat-soluble vitamin, is also prevalent in adolescents; therefore, it is possible that the high prevalence of vitamin D deficiency is related to decreased fat intake. Further studies are required to elucidate the possible role of vitamin D in the pathogenesis and clinical management of AIS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
