Novel Mapping Method for the Intraoperative Neurophysiologic Monitoring of Sexual Function During Prostate Surgery.

Autor:	Martín-Palomeque G; Clinical Neurophysiology Department, Hospital Ramón y Cajal, Madrid, Spain., Cabañes-Martínez L; Clinical Neurophysiology Department, Hospital Ramón y Cajal, Madrid, Spain., de Blas Beorlegui G; Clinical Neurophysiology Department, Hospital Ramón y Cajal, Madrid, Spain., Moreno Galera MDM; Clinical Neurophysiology Department, Hospital Ramón y Cajal, Madrid, Spain., López JR; Departments of Neurology & Neurological Sciences and Neurosurgery, Stanford University School of Medicine, Stanford, California, USA., Burgos FJ; Urology Department, Hospital Ramón y Cajal, Madrid, Spain., Regidor Bailly-Baillière I; Clinical Neurophysiology Department, Hospital Ramón y Cajal, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society [J Clin Neurophysiol] 2018 Nov; Vol. 35 (6), pp. 463-467.
DOI:	10.1097/WNP.0000000000000506
Abstrakt:	Purpose: The occurrence of urinary incontinence and erectile dysfunction after surgical treatment for prostate cancer is a significant and lingering problem. The aim of this study is to revise and improve older techniques of intraoperative cavernous nerve mapping already in use to improve accuracy and reliability. Methods: We prospectively studied this technique in 12 patients suffering from prostate cancer. Inhalation or intravenous anesthetic regimen was used with nondepolarizing muscle relaxants. Stimulation protocol was 30 Hz, 0.2 ms, 10 to 20 mA intensity and a maximum duration of 30 seconds. Recording was performed with a system for measuring pressure changes using a stainless steel needle electrode inside the cavernous bodies. Stimulation was systematically performed at three distinct moments during the surgery at various points. An increase or decrease in pressure of 4 cm of H20 in the cavernous bodies was considered a positive result and negative response when no changes occurred after 30 seconds of continuous stimulation. Results: Of patients, 91.6% had positive responses to initial stimulation. The anesthetic regimen did not appear to significantly influence the responses in our series. Conclusions: In light of the results of this study, the stimulation of the cavernous nerves may be a viable technique in the right context, which includes good patient selection (young patients with a localized tumor and with preserved potency). The major limitation is that mapping techniques are useful to localize functional nerves, but not to monitor function in a continuous manner.
Databáze:	MEDLINE
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