Circulating concentrations of B group vitamins and urothelial cell carcinoma.

Autor: Bassett JK; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia., Brinkman MT; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia., Dugué PA; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia., Ueland PM; Department of Clinical Science, University of Bergen, Bergen, Norway.; Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway., Midttun Ø; Bevital AS, Bergen, Norway., Ulvik A; Bevital AS, Bergen, Norway., Bolton D; Department of Surgery, Austin Health, University of Melbourne, VIC, Australia., Southey MC; Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences, Monash University, Clayton, VIC, Australia., English DR; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia., Milne RL; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia., Hodge AM; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia., Giles GG; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2019 Apr 15; Vol. 144 (8), pp. 1909-1917. Date of Electronic Publication: 2018 Dec 03.
DOI: 10.1002/ijc.31927
Abstrakt: B-group vitamins, as components of the one carbon metabolism pathway, are involved in DNA synthesis, repair and methylation. Our aim was to investigate associations between circulating plasma levels of B vitamins and urothelial cell carcinoma (UCC). We conducted a nested case-control study of UCC within the Melbourne Collaborative Cohort Study. B vitamins were measured in pre-diagnostic plasma samples. Conditional logistic regression was used to estimate odds ratios (OR) for UCC risk associated with circulating B vitamins in 363 matched cases and controls. In a case-only analysis (N = 390), hazard ratios (HR) for overall survival associated with plasma B vitamins were estimated using Cox regression. There were no strong associations between UCC risk and pre-diagnostic levels of plasma B vitamins. No heterogeneity in UCC risk was observed by subtype (invasive or superficial), sex, smoking status or alcohol intake. There was no heterogeneity by country of birth for most B vitamins, except for folate (p-homogeneity = 0.03). In UCC cases, there were no strong associations between plasma B vitamins and overall survival. We found no associations between pre-diagnostic plasma concentrations of B-group vitamins and UCC risk or survival.
(© 2018 UICC.)
Databáze: MEDLINE
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