Does pregnancy alter life-course lipid trajectories? Evidence from the HUNT Study in Norway.

Autor:	Markovitz AR; Department of Epidemiology Harvard T.H. Chan School of Public Health, Boston, MA amarkovitz@mail.havard.edu.; Connors Center for Women's Health and Gender Biology Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Haug EB; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway., Horn J; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Fraser A; Population Health Sciences, Bristol Medical School and MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK., Macdonald-Wallis C; Population Health Sciences, Bristol Medical School and MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK., Tilling K; Population Health Sciences, Bristol Medical School and MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK., Rimm EB; Department of Epidemiology Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Missmer SA; Department of Epidemiology Harvard T.H. Chan School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA.; Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI., Williams PL; Department of Epidemiology Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA., Romundstad PR; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Rich-Edwards JW; Department of Epidemiology Harvard T.H. Chan School of Public Health, Boston, MA.; Connors Center for Women's Health and Gender Biology Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jazyk:	angličtina
Zdroj:	Journal of lipid research [J Lipid Res] 2018 Dec; Vol. 59 (12), pp. 2403-2412. Date of Electronic Publication: 2018 Oct 12.
DOI:	10.1194/jlr.P085720
Abstrakt:	We examined the association between pregnancy and life-course lipid trajectories. Linked data from the Nord-Trøndelag Health Study and the Medical Birth Registry of Norway yielded 19,987 parous and 1,625 nulliparous women. Using mixed-effects spline models, we estimated differences in nonfasting lipid levels from before to after first birth in parous women and between parous and nulliparous women. HDL cholesterol (HDL-C) dropped by -4.2 mg/dl (95% CI: -5.0, -3.3) from before to after first birth in adjusted models, a 7% change, and the total cholesterol (TC) to HDL-C ratio increased by 0.18 (95% CI: 0.11, 0.25), with no change in non-HDL-C or triglycerides. Changes in HDL-C and the TC/HDL-C ratio associated with pregnancy persisted for decades, leading to altered life-course lipid trajectories. For example, parous women had a lower HDL-C than nulliparous women at the age of 50 years (-1.4 mg/dl; 95% CI: -2.3, -0.4). Adverse changes in lipids were greatest after first birth, with small changes after subsequent births, and were larger in women who did not breastfeed. Findings suggest that pregnancy is associated with long-lasting adverse changes in HDL-C, potentially setting parous women on a more atherogenic trajectory than prior to pregnancy. (Copyright © 2018 Markovitz et al. Published by The American Society for Biochemistry and Molecular Biology, Inc.)
Databáze:	MEDLINE
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