Dietary Fiber Intake: Its Relation With Glycation End Products and Arterial Stiffness in End-Stage Renal Disease Patients.
| Autor: | Demirci BG; Department of Nephrology, Ankara Ataturk Education and Reseach Hospital, Ankara, Turkey. Electronic address: bahargurlek@gmail.com., Tutal E; Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey., Eminsoy IO; Department of Nutrition, Baskent University Faculty of Medicine, Ankara, Turkey., Kulah E; Department of Nephrology, Baskent University Faculty of Medicine, Istanbul, Turkey., Sezer S; Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation [J Ren Nutr] 2019 Mar; Vol. 29 (2), pp. 136-142. Date of Electronic Publication: 2018 Oct 09. |
| DOI: | 10.1053/j.jrn.2018.08.007 |
| Abstrakt: | Objective: We aimed to analyze the relationship between the effect of total dietary fiber intake on C-reactive protein (CRP) and on oxidative stress parameters such as serum advanced glycation end products (AGEs), superoxide dysmutase (SOD), malondialdehyde, and arterial stiffness by pulse wave velocity (PWv) in maintanace hemodialysis (MHD) patients. Methods: Among 650 MHD patients, 128 were selected according to inclusion criteria. The dietary survey was performed with a 3-day dietary history. Dietary fiber level was adjusted for total energy intake by the residual method. Patients were stratified by quartiles of adjusted dietary fiber (ADF) level as group 1 (n = 32) (ADF: <8.86 g/day), group 2 (n = 35) (ADF: 8.86-12.50 g/day), group 3 (n = 31) (ADF: 12.51-15.90 g/day), and group 4 (n = 30) (ADF: ≥15.91 g/day). Monthly assessed biochemical parameters including serum hemoglobin, albumin, CRP, calcium, phosphorus, and lipid profile levels were recorded. Serum AGEs, SOD, and malondialdehyde levels were determined by ELISA method. The PWv was determined from pressure tracing over carotid and femoral arteries. Results: Patients in group 3 and 4 had significantly lower CRP and AGE than those in group 1 and 2. Mean serum SOD level and PWv were significantly higher in group 4. In regression analysis, ADF intake was the unique predictor for both AGE (r 2 = 0.164, P = 0.017) and CRP levels (r 2 = 0.238, P = 0.01). Conclusion: Present data show that dietary fiber intake is independently correlated with inflammation and oxidative stress. In addition, decreased fiber intake results in impaired arterial stiffness. Thus, adequate fiber intake could prevent cardiovascular events and inflammatory processes in patients undergoing MHD. (Copyright © 2018 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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